Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease
文献类型：期刊论文
| 作者 | Jiang, Yuting1,3; Chen, Jie1,3; Du, Yaoyao1,3; Fan, Minwei2; Shen, Lan3 |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2025-05-08 |
| 卷号 | 154页码:13 |
| 关键词 | Inflammatory bowel disease Mucosal barrier Epithelium Immune cells |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2025.114462 |
| 通讯作者 | Fan, Minwei(fanmw0455_cn@sina.com) ; Shen, Lan(alansusu@sina.com) |
| 英文摘要 | Inflammatory bowel disease (IBD) is an inflammatory disease of the intestine whose primary pathological presentation is the destruction of the intestinal epithelium. The intestinal epithelium, located between the lumen and lamina propria, transmits luminal microbial signals to the immune cells in the lamina propria, which also modulate the intestinal epithelium. In IBD patients, intestinal epithelial cells (IECs) die dysfunction and the mucosal barrier is disrupted, leading to the recruitment of immune cells and the release of cytokines. In this review, we describe the structure and functions of the intestinal epithelium and mucosal barrier in the physiological state and under IBD conditions, as well as the patterns of epithelial cell death and how immune cells modulate the intestinal epithelium providing a reference for clinical research and drug development of IBD. In addition, according to the targeting of epithelial apoptosis and necroptotic pathways and the regulation of immune cells, we summarized some new methods for the treatment of IBD, such as necroptosis inhibitors, microbiome regulation, which provide potential ideas for the treatment of IBD. This review also describes the potential for integrating AI-driven approaches into innovation in IBD treatments. |
| WOS关键词 | INNATE LYMPHOID-CELLS ; NF-KAPPA-B ; PROMOTES MUCOSAL REPAIR ; TIGHT JUNCTION PROTEIN ; BARRIER FUNCTION ; INTESTINAL INFLAMMATION ; PANETH CELLS ; ANTIMICROBIAL DEFENSE ; INTERFERON-GAMMA ; NKT CELLS |
| 资助项目 | Program of Shanghai Committee of Science and Technology, China[22S21902900] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001468642200001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317488]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fan, Minwei; Shen, Lan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut Res, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Sch Med,State Key Lab Syst Med Canc, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cai lun Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Yuting,Chen, Jie,Du, Yaoyao,et al. Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2025,154:13. |
| APA | Jiang, Yuting,Chen, Jie,Du, Yaoyao,Fan, Minwei,&Shen, Lan.(2025).Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease.INTERNATIONAL IMMUNOPHARMACOLOGY,154,13. |
| MLA | Jiang, Yuting,et al."Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease".INTERNATIONAL IMMUNOPHARMACOLOGY 154(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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