Exploring and expanding the natural chemical space of bacterial diterpenes
文献类型：期刊论文
| 作者 | Wei, Xiuting5; Ning, Wenbo5; Mccadden, Caitlin A.5; Alsup, Tyler A.5; Li, Zining2,4,5; Lomowska-Keehner, Diana P.5; Nafie, Jordan6; Qu, Tracy5; Opoku, Melvin Osei5; Gillia, Glen R.5 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2025-04-19 |
| 卷号 | 16期号:1页码:9 |
| DOI | 10.1038/s41467-025-57145-6 |
| 通讯作者 | Rudolf, Jeffrey D.(jrudolf@chem.ufl.edu) |
| 英文摘要 | Terpenoids are the largest family of natural products but relatively rare in bacteria. Genome mining reveals widespread prevalence of terpene synthases, the enzymes responsible for constructing the hydrocarbon skeletons, in bacteria. Here, we show that 125 (37%) of 334 terpene synthases from 8 phyla, 17 classes, and 83 genera of bacteria are active as diterpene synthases. Isolation and structural elucidation of 28 diterpenes from 31 terpene synthases reveal three previously unreported terpene skeletons, skeletons of natural products from other organisms with unknown biosynthetic pathways, diterpenes that are known in other organisms but to the best of our knowledge not previously seen in bacteria, or new structural and stereochemical isomers of diterpenes. We also identify type I diterpene synthases from myxobacteria and cyanobacteria. This study will help to discover new natural products, advance studies in terpenoid biosynthesis and enzymology, and provide model systems to probe the ecological roles of terpenes. |
| WOS关键词 | TERPENE SYNTHASE GENES ; SESTERTERPENE SYNTHASE ; CLAVULARIA-INFLATA ; IDENTIFICATION ; CYCLASES ; FAMILY ; DI |
| 资助项目 | U.S. Department of Health & Human Services | National Institutes of Health (NIH)[R35 GM142574] ; National Institutes of Health ; University of Florida[DE-AC02-05CH11231] ; University of Florida[T32 GM136583] ; U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility[DGE-2236414] ; National Science Foundation Graduate Research Fellowship[S10 OD021758-01A1] ; NIH |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001471191400012 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317506]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Rudolf, Jeffrey D. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Zhangjiang Hitech Pk, Shanghai, Peoples R China 2.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist & Sichuan Prov, Chengdu, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China 4.Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu, Peoples R China 5.Univ Florida, Dept Chem, Gainesville, FL 32611 USA 6.Biotools Inc, Jupiter, FL USA |
| 推荐引用方式 GB/T 7714 | Wei, Xiuting,Ning, Wenbo,Mccadden, Caitlin A.,et al. Exploring and expanding the natural chemical space of bacterial diterpenes[J]. NATURE COMMUNICATIONS,2025,16(1):9. |
| APA | Wei, Xiuting.,Ning, Wenbo.,Mccadden, Caitlin A..,Alsup, Tyler A..,Li, Zining.,...&Rudolf, Jeffrey D..(2025).Exploring and expanding the natural chemical space of bacterial diterpenes.NATURE COMMUNICATIONS,16(1),9. |
| MLA | Wei, Xiuting,et al."Exploring and expanding the natural chemical space of bacterial diterpenes".NATURE COMMUNICATIONS 16.1(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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