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Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

文献类型：期刊论文

作者Liu, Guobin2; Chen, Lu3; Zhao, Jingxiang2,4,5; Jiang, Yue6; Guo, Yarong7; Mao, Xiang8; Ren, Xuelian2,9; Liu, Kun6; Mei, Qi1; Li, Qunyi3
刊名ADVANCED SCIENCE
出版日期2025-04-26
页码15
关键词clinical relevance colorectal cancer functions glycoproteomics intact N-glycopeptides
DOI10.1002/advs.202415645
通讯作者Mei, Qi(meiqi_tj@hust.edu.cn) ; Li, Qunyi(liqunyi@huashan.org.cn) ; Huang, He(hhuang@simm.ac.cn)
英文摘要Colorectal cancer (CRC) progression is driven by complex metabolic alterations, including aberrant N-glycosylation patterns that critically influence tumor development. However, the metabolic and functional roles of N-glycosylation in CRC remain poorly understood. Herein, comprehensive proteomic and N-linked intact glycoproteomics analyses are performed on 45 CRC tumors, and normal adjacent tissues (NATs) are matched, identifying 7125 intact N-glycopeptides from 704 glycoproteins. Through analysis of glycoform expression profiles and structural characteristics, a glycosylation site-protein function association network is constructed to uncover metabolic dysregulation driven by N-glycosylation in CRC. Moreover, an arithmetic model is developed that integrates N-glycan expression patterns, which effectively distinguishes tumors from NATs, reflecting metabolic reprogramming in cancer. These findings identify Chloride Channel Accessory 1 (CLCA1) and Olfactomedin 4 (OLFM4) as potential metabolic biomarkers for CRC diagnosis. Immunohistochemistry and Cox regression analyses validated the prognostic power of these markers. Notably, the critical role of specific N-glycosylation at N196 of Adipocyte plasma membrane-associated protein (APMAP) is highlighted, a key player in tumor metabolism and CRC progression, providing a potential target for therapeutic intervention. These findings offer valuable insights into the metabolic roles of N-glycosylation in CRC, advancing biomarker discovery, enhancing metabolic-based diagnostic precision, and improving personalized treatment strategies targeting cancer metabolism.
WOS关键词EMERGING ROLES ; FAMILY ; EGFR
资助项目Shanghai Municipal Science and Technology Major Project ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1060000] ; National Natural Science Foundation of China[22277125] ; National Natural Science Foundation of China[92253306] ; Natural Science Foundation of Shanghai[23ZR1474600] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001475888500001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/317527]  
专题中国科学院上海药物研究所
通讯作者Mei, Qi; Li, Qunyi; Huang, He
作者单位1.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Pharm, Shanghai 200040, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
6.Northeastern Univ, Sch Mech Engn & Automat, Shenyang 110819, Peoples R China
7.Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Digest Syst Oncol,Hosp 3, Taiyuan 030032, Peoples R China
8.Fudan Univ, Huashan Hosp, Dept Surg, Shanghai 200040, Peoples R China
9.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Guobin,Chen, Lu,Zhao, Jingxiang,et al. Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling[J]. ADVANCED SCIENCE,2025:15.
APA Liu, Guobin.,Chen, Lu.,Zhao, Jingxiang.,Jiang, Yue.,Guo, Yarong.,...&Huang, He.(2025).Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling.ADVANCED SCIENCE,15.
MLA Liu, Guobin,et al."Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling".ADVANCED SCIENCE (2025):15.

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来源：上海药物研究所

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