Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications
文献类型：期刊论文
| 作者 | Hong, Li-li1,2; Cui, Dian-xin1,2; Wang, Hong-da1,2; Jing, Qi1,2; Li, Xue1,2; Hu, Ying1; Yao, Yi-qing1,2; Gao, Xiu-mei1,2,3; Guo, De-an1,2,4 ; Yang, Wen-zhi1,2,3
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| 刊名 | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 189页码:22 |
| 关键词 | Traditional Chinese medicine metabolism Bio-samples pre-treatment Mass spectrometry Data acquisition Data processing Application |
| ISSN号 | 0165-9936 |
| DOI | 10.1016/j.trac.2025.118269 |
| 通讯作者 | Gao, Xiu-mei(gaoxiumei@tjutcm.edu.cn) ; Guo, De-an(daguo@simm.ac.cn) ; Yang, Wen-zhi(wzyang0504@tjutcm.edu.cn) |
| 英文摘要 | Understanding of how complex traditional Chinese medicine (TCM) components are absorbed, distributed, metabolized, and eliminated is crucial to determine the impacts of the exogenous chemicals (prototypes and metabolites) to the organism (humans and animals). Mass spectrometry (MS)-oriented analytical strategies, combined with versatile analysis tools, have been predominantly utilized to comprehensively decipher TCM metabolism. Among the entire workflows involved in TCM metabolism occurring in the last decade, great advances are gained regarding the bio-samples pre-treatment, MS data acquisition, and data processing. By focusing on the biological samples pre-treatment, state-of-the-art data acquisition and data processing strategies relying on MS, we comparatively outline the basic principles and characteristics of the developed analytical techniques reported from 2015 to 2024, and the typical applications in various scenarios of TCM metabolism, based on 964 related publications. It is expected to offer a methodological reference to the researchers in metabolism studies of TCM and its various components. |
| WOS关键词 | SOLID-PHASE EXTRACTION ; LIQUID-LIQUID MICROEXTRACTION ; MASS-SPECTROMETRY ; RAT PLASMA ; DEPENDENT ACQUISITION ; DRUG DISCOVERY ; ECLIPTAE HERBA ; IN-VITRO ; CHROMATOGRAPHY ; IDENTIFICATION |
| 资助项目 | National Natural Science Foundation of China[82192914] ; National Natural Science Foundation of China[82374030] ; Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines[24ZXZKSY00010] ; Tianjin Outstanding Youth Fund[23JCJQJC00030] ; China Postdoctoral Science Foundation[2024M762390] ; Postdoctoral Fellowship Program of CPSF[GZB20240531] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001475204600001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317533]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gao, Xiu-mei; Guo, De-an; Yang, Wen-zhi |
| 作者单位 | 1.Tianjin Univ Tradit Chinese Med, State Key Lab Chinese Med Modernizat, 10 Poyanghu Rd, Tianjin 301617, Peoples R China 2.Haihe Lab Modern Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, 10 Poyanghu Rd, Tianjin 301617, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Li-li,Cui, Dian-xin,Wang, Hong-da,et al. Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2025,189:22. |
| APA | Hong, Li-li.,Cui, Dian-xin.,Wang, Hong-da.,Jing, Qi.,Li, Xue.,...&Yang, Wen-zhi.(2025).Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,189,22. |
| MLA | Hong, Li-li,et al."Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 189(2025):22. |
入库方式： OAI收割
来源：上海药物研究所
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