Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1
文献类型：期刊论文
| 作者 | Zhu, Ming-Xin1,2,3; Hao, Yi1,2; Yan, Bing-Yuan1,2; Jin, Yang1,2; Gao, Zhen1,2; Li, Xu-Wen1,2,3
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2025-04-29 |
| 页码 | 7 |
| 关键词 | antibacterial activities
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| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202500919 |
| 通讯作者 | Li, Xu-Wen(xwli@simm.ac.cn) |
| 英文摘要 | One new phenolic derivative diameliresorcin (1), one new natural product N-(2 '-oxopiperidin-3 '-yl) picolinamide (2), one new alpha-pyrone derivative diameliphyone (3), and six known secondary metabolites (4-9) were isolated from the Ligia exotica-derived fungus Diaporthe melitensis HZ-1. The structures of three new compounds were identified by IR, NMR, and HR-ESI-MS, whereas their absolute configurations were validated either through single-crystal x-ray diffraction analysis or via time-dependent density functional theory (TDDFT)-electronic circular dichroism (ECD) calculations. It is noted that the absolute configuration of compound 2 was determined for the first time. Meanwhile, all the isolated compounds were evaluated for their antibacterial activities. Among them, diameliresorcin (1) exhibited weak anti-Vibrio vulnificus activity with minimum inhibitory concentration (MIC) value of 46 mu g/mL. |
| WOS关键词 | ANTIBACTERIAL ; DERIVATIVES |
| 资助项目 | National Key Research and Development Program of China[2021YFF0502400] ; Shandong Laboratory Program[SYS202205] ; Taishan Scholars Program[tsqn 202312302] ; Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City[2023JCYJ057] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001478456700001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317557]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Xu-Wen |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Ming-Xin,Hao, Yi,Yan, Bing-Yuan,et al. Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1[J]. CHEMISTRY & BIODIVERSITY,2025:7. |
| APA | Zhu, Ming-Xin,Hao, Yi,Yan, Bing-Yuan,Jin, Yang,Gao, Zhen,&Li, Xu-Wen.(2025).Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1.CHEMISTRY & BIODIVERSITY,7. |
| MLA | Zhu, Ming-Xin,et al."Diverse Secondary Metabolites From the Ligia exotica-Derived Fungus Diaporthe melitensis HZ-1".CHEMISTRY & BIODIVERSITY (2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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