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Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling

文献类型：期刊论文

作者Ma, Xiaolong1,4; Miao, Erfei1,4; Sun, Yili1,4; Sun, Longkang1,4,5; Huang, Chaoying1,3,4; Zhang, Xun2; Hou, Ke-Qiang1,4; Xu, Zhongliang1,4; Zang, Yi1,4; Bi, Tongyu1,4
刊名ORGANIC LETTERS
出版日期2025-04-24
卷号27期号:18页码:4753-4761
ISSN号1523-7060
DOI10.1021/acs.orglett.5c01198
通讯作者Zang, Yi(yzang@simm.ac.cn) ; Bi, Tongyu(s19-bitongyu@simm.ac.cn) ; Yang, Weibo(yweibo@simm.ac.cn)
英文摘要Herein, we report a novel ligand-switchable Pd-catalyzed carbene coupling reaction employing vinylethylene carbonates and sulfoxonium ylides. By proper choice of ligands, the chemoselectivity of the process could be efficiently regulated, allowing for the availability of dihydrofuran or dienol scaffolds. This method features mild reaction conditions, broad scope, and remarkable synthetic utility. Compound 6f can effectively stimulate the secretion of GLP-1, providing promising insight into the development of small-molecule agonists for the GLP-1 receptor.
WOS关键词SULFOXONIUM YLIDES ; VINYLETHYLENE CARBONATES ; CONSTRUCTION ; ACCESS
资助项目National Natural Science Foundation of China[82373708] ; National Natural Science Foundation of China[22171275] ; National Natural Science Foundation of China[2023695] ; Shanghai Postdoctoral Excellence Program[GZC20232843] ; Postdoctoral Fellowship Program of CPSF
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001474270000001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/317566]  
专题中国科学院上海药物研究所
通讯作者Zang, Yi; Bi, Tongyu; Yang, Weibo
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Key Lab Receptor Res, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210000, Peoples R China
3.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Xiaolong,Miao, Erfei,Sun, Yili,et al. Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling[J]. ORGANIC LETTERS,2025,27(18):4753-4761.
APA Ma, Xiaolong.,Miao, Erfei.,Sun, Yili.,Sun, Longkang.,Huang, Chaoying.,...&Yang, Weibo.(2025).Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling.ORGANIC LETTERS,27(18),4753-4761.
MLA Ma, Xiaolong,et al."Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling".ORGANIC LETTERS 27.18(2025):4753-4761.

入库方式： OAI收割

来源：上海药物研究所

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