Recent advances in the synthesis of poly (ADP-ribose)
文献类型：期刊论文
| 作者 | Wu, Yidan1,3; Tang, Li1,3; Liu, Qiang1,2,3 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 125页码:13 |
| 关键词 | ADP-ribosylation Poly ADP-ribose Oligosaccharides Solid phase synthesis Pyrophosphate |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2025.118202 |
| 通讯作者 | Liu, Qiang(liuqiang@simm.ac.cn) |
| 英文摘要 | Poly (ADP-ribose) (PAR), a dynamic and reversible post-translational modification, is a structurally complex biopolymer synthesized via ADP-ribosylation, utilizing NAD+ as a substrate and catalyzed by ADPribosyltransferases (ARTs). PAR exists as linear or branched chains of up to 200 ADP-ribose units, playing pivotal roles in DNA repair, chromatin remodeling, transcriptional regulation, and cell death. The structural intricacy of PAR-marked by labile pyrophosphate linkages, stereochemical diversity, and branching architectures-poses significant synthetic challenges, necessitating innovative strategies integrating carbohydrate chemistry, enzymatic engineering, and phosphate coupling. Recent advances over the past decade have enabled the chemical and chemoenzymatic synthesis of well-defined PAR fragments, oligomers, and probes, facilitating breakthroughs in structural biology, interactome mapping, and therapeutic discovery. This review highlights key methodologies, including phosphoramidite-based assembly, development of photoaffinity probes and chemoenzymatic elongation with engineered ARTs, which collectively advance our understanding of PAR's biological functions and therapeutic potential. |
| WOS关键词 | ADENOSINE-DIPHOSPHATE RIBOSE ; CHEMICAL BIOLOGY ; POLY(ADP-RIBOSE) ; RIBOSYLATION ; INSIGHTS ; ACTIVATION ; STRATEGY |
| 资助项目 | National Natural Science Foun-dation of China[22207114] ; National Natural Science Foun-dation of China[22477143] ; Science and Technology Com-mission of Shanghai Municipality[22PJ1415600] ; Zhongshan Science and Technology Bureau[CXTD2022012] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001479867200001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317569]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, Shanghai 201203, Peoples R China 2.Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yidan,Tang, Li,Liu, Qiang. Recent advances in the synthesis of poly (ADP-ribose)[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2025,125:13. |
| APA | Wu, Yidan,Tang, Li,&Liu, Qiang.(2025).Recent advances in the synthesis of poly (ADP-ribose).BIOORGANIC & MEDICINAL CHEMISTRY,125,13. |
| MLA | Wu, Yidan,et al."Recent advances in the synthesis of poly (ADP-ribose)".BIOORGANIC & MEDICINAL CHEMISTRY 125(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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