Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation
文献类型：期刊论文
| 作者 | Lin, Shuru2,3; Qi, Zhengfei1,2,4; Yu, Quanxiang2; Ma, Rui2; Zhang, Kexin2; Jiang, Wenqi2; Mai, Yilin2; Fu, Qingshan Bill1,2,3,4 |
| 刊名 | ACS OMEGA
 |
| 出版日期 | 2025-04-29 |
| 卷号 | 10期号:18页码:18338-18346 |
| ISSN号 | 2470-1343 |
| DOI | 10.1021/acsomega.4c09709 |
| 通讯作者 | Fu, Qingshan Bill(fuqingshan@simm.ac.cn) |
| 英文摘要 | Reptile reoviruses encode the p14 fusion-associated small transmembrane (FAST) protein, which induces cell-cell membrane fusion as a nonstructural protein. When the virus enters the host cell, the p14 protein is encoded, synthesized, and delivered to the plasma membrane via the endoplasmic reticulum-Golgi transport system. During this process, the polybasic motif (PBM) at the proximal membrane terminal of the p14 cytosolic endodomain interacts with Rab11 on the Golgi. This interaction places p14 into vesicles enclosed by the AP-1 adaptor, transporting it to the plasma membrane and causing membrane fusion. In this study, we used the surface plasmon resonance principle to confirm that p141-69 had a substantial affinity for Rab11 at the membrane, and we also proved at the cellular level that Rab11 directly increased p14-induced syncytium formation and improved membrane fusion efficiency. We also found preliminary evidence that p141-69 could act as a fusion peptide to trigger liposome-cell fusion. |
| WOS关键词 | REPTILIAN REOVIRUS ; FUSION ; AQUAREOVIRUS |
| 资助项目 | National Natural Science Foundation of China[32271320] ; Creative Research Group of Zhongshan City (Lingnan Pharmaceutical Research and Innovation team)[CXTD2022011] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001479271100001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317575]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fu, Qingshan Bill |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Peoples R China 3.Guangzhou Univ Chinese Med, Coll Chinese Med, Guangzhou 510006, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Shuru,Qi, Zhengfei,Yu, Quanxiang,et al. Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation[J]. ACS OMEGA,2025,10(18):18338-18346. |
| APA | Lin, Shuru.,Qi, Zhengfei.,Yu, Quanxiang.,Ma, Rui.,Zhang, Kexin.,...&Fu, Qingshan Bill.(2025).Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation.ACS OMEGA,10(18),18338-18346. |
| MLA | Lin, Shuru,et al."Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation".ACS OMEGA 10.18(2025):18338-18346. |
入库方式： OAI收割
来源：上海药物研究所
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