中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis

文献类型：期刊论文

作者Chen, Dan2; Chen, Yifan3; Liu, Jianwen2; Liu, Xinyue2; Liu, Peiwen4; Zhan, Jiabing2; Chen, Zhiting5; Gan, Yong1,6; Huang, Mingdong4; Chen, Zhaoyang2
刊名SCIENCE ADVANCES
出版日期2025-05-02
卷号11期号:18页码:16
ISSN号2375-2548
DOI10.1126/sciadv.adu6676
通讯作者Huang, Mingdong(HMD_lab@fzu.edu.cn) ; Chen, Zhaoyang(chenzhaoyang888@126.com)
英文摘要Arterial thrombosis is commonly accompanied by poor recanalization and high recurrence, typically caused by a fibrinolysis-resistant microenvironment. We identify elevated levels of plasminogen activator inhibitor-1 (PAI-1) and, notably, its strong correlation with inflammation in arterial thrombosis. To address this, small molecular inhibitors of PAI-1 and inflammation are used as bioregulators to restore vascular homeostasis. We design a carrier-free supramolecular system based on the bioregulators-tuned self-assembly of a near-infrared thrombus probe, which preferentially forms protein corona in situ to enhance plasma stability. Under acidic conditions and increased shear stress, the supramolecular assemblies disintegrate, enabling site-specific cargo release. In vivo, the probe accumulates 22.8-fold more in the thrombotic than contralateral artery. Functionally, this nanomedicine improves outcomes in mice with carotid artery thrombosis and chronic cerebral ischemia. Mechanistically, it down-regulates NF-kappa B signaling, inhibits NETosis and glycolysis, and up-regulates cGMP-mediated signaling, thereby alleviating inflammation and promoting fibrinolysis. This study offers an innovative codelivery strategy using supramolecular assemblies to advance therapies for arterial thrombosis.
WOS关键词PLASMINOGEN-ACTIVATOR INHIBITOR-1 ; THROMBOLYTIC THERAPY ; ENDOTHELIAL-CELLS ; PLATELETS ; OCCLUSION ; ZINC
资助项目National Natural Science Foundation of China[82270445] ; National Natural Science Foundation of China[32371312] ; National Natural Science Foundation of China[22077016] ; Excellent Young Scholars Cultivation Project of Fujian Medical University Union Hospital[2022XH020] ; National Key R&D Program of China[2023YFE 0118400] ; Joint Funds for the innovation of Science and Technology of Fujian province[2023Y9184]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001480343000009
出版者AMER ASSOC ADVANCEMENT SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/317581]  
专题中国科学院上海药物研究所
通讯作者Huang, Mingdong; Chen, Zhaoyang
作者单位1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
2.Fujian Med Univ, Heart Ctr Fujian Prov, Dept Cardiol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China
3.Xiamen Univ, Xiamen Cardiovasc Hosp, Dept Cardiol, Xiamen 361004, Fujian, Peoples R China
4.Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China
5.Fujian Med Univ, Union Hosp, Dept Neurol, Fuzhou 350001, Fujian, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Dan,Chen, Yifan,Liu, Jianwen,et al. In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis[J]. SCIENCE ADVANCES,2025,11(18):16.
APA Chen, Dan.,Chen, Yifan.,Liu, Jianwen.,Liu, Xinyue.,Liu, Peiwen.,...&Chen, Zhaoyang.(2025).In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis.SCIENCE ADVANCES,11(18),16.
MLA Chen, Dan,et al."In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis".SCIENCE ADVANCES 11.18(2025):16.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。