Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization
文献类型：期刊论文
| 作者 | Li, Ludi3; Chen, Bo3; Cao, Wenxu1,2; Babu, G. V. Surendra2; Liao, Weike3; Zhang, Pengli2; Xia, Guoqin1,2,3 |
| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2025-04-29 |
| 页码 | 7 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d5qo00590f |
| 通讯作者 | Zhang, Pengli(zhangpengli@zidd.ac.cn) ; Xia, Guoqin(xiaguoqin@simm.ac.cn) |
| 英文摘要 | Three-dimensional chiral cyclic frameworks containing multiple stereocenters are prevalent skeletons in natural products and bioactive molecules. Nevertheless, the synthetic methods for these architectures are limited to date. In this study, an efficient synthetic route for cyclic chiral amines with two adjacent stereocenters was developed by employing symmetric cyclopentenylamine derivatives as starting materials. This reaction demonstrates a broad substrate scope with various functional groups, resulting in excellent yields and stereoselectivities. The proposed mechanism involves a sophisticated sequence of NiH species-mediated transformations, including NiH insertion, beta-hydride elimination, reversed NiH insertion and alkylation steps, which collectively enable the precise construction of these complex chiral architectures. |
| WOS关键词 | DESIGN ; REMOTE |
| 资助项目 | National Natural Science Foundation of China[22271297] ; National Natural Science Foundation of China[2021QN020533] ; Program for Talented Young Investigators of Guangdong Province[CXTD2023009] ; Zhongshan Science and Technology Bureau |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001480105400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317599]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Pengli; Xia, Guoqin |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Guizhou Med Univ, Sch Pharmaceut Sci, State Key Lab Discovery & Utilizat Funct Component, Guiyang 550014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ludi,Chen, Bo,Cao, Wenxu,et al. Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization[J]. ORGANIC CHEMISTRY FRONTIERS,2025:7. |
| APA | Li, Ludi.,Chen, Bo.,Cao, Wenxu.,Babu, G. V. Surendra.,Liao, Weike.,...&Xia, Guoqin.(2025).Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization.ORGANIC CHEMISTRY FRONTIERS,7. |
| MLA | Li, Ludi,et al."Enantioselective construction of cycloalkyl amines via nickel-catalysed alkene desymmetrization".ORGANIC CHEMISTRY FRONTIERS (2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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