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Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice

文献类型：期刊论文

作者Qi, Chuchu1; Sima, Wenqi1; Mao, Honghui1; Hu, Erling1; Ge, Junye1; Deng, Mao3; Chen, Andi1; Ye, Weiyi3; Xue, Qian1; Wang, Wenting1,2
刊名NATURE COMMUNICATIONS
出版日期2025-05-04
卷号16期号:1页码:18
DOI10.1038/s41467-025-59473-z
通讯作者Wang, Wenting(wwt0657@fmmu.edu.cn) ; Chen, Qian(chenqian@zidd.ac.cn) ; Wu, Shengxi(shengxi@fmmu.edu.cn)
英文摘要The anterior cingulate cortex (ACC) is essential for social behavior, and its dysfunction is implicated in social interaction deficits in autism. Pyramidal neuron activity in the ACC is modulated by parvalbumin (PV) and somatostatin (SST) interneurons, though their specific roles in social interactions remain unclear. Here, we demonstrate that PV and SST interneurons differentially contribute to the regulation of social interactions. In a Shank3-deficient autistic model, the expression of Kcnh7, a risk gene for autism, is reduced in both PV and SST interneurons. Knocking out Kcnh7 in either interneuron subtype leads to social interaction deficits. Furthermore, projections from the lateral posterior thalamic nucleus (mediorostral part, LPMR) to PV interneurons and from the ventral hippocampus (vHPC) to SST interneurons differentially modulate social interactions. These findings provide new insights into the distinct roles of PV and SST interneurons in social processes and their contributions to autism-related pathophysiology.
WOS关键词CIRCUIT ; CONNECTIVITY ; MECHANISMS ; PREFERENCE ; DYNAMICS ; NEURONS ; NOVELTY ; DISPLAY
资助项目National Natural Science Foundation of China (National Science Foundation of China)[82221001] ; National Natural Science Foundation of China (National Science Foundation of China)[82271577] ; National Natural Science Foundation of China (National Science Foundation of China)[82071536] ; National Natural Science Foundation of China (National Science Foundation of China)[82271578] ; Natural Science Foundation of China[2020ZDLSF01-09] ; Shaanxi Provincial Key Research and Development Program[2023-ZDLSF-47] ; Shaanxi Provincial Innovation Chain Project of Key Industries[2024SF-YBXM-033] ; Shaanxi Province Key Research and Development Plan[LHJJ24JH05] ; Joint Founding Project of Innovation Research Institute, Xijing Hospital[22PJ1415500] ; Shanghai Pujiang Program[CXTD2022013] ; Zhongshan Municipal Bureau of Science and Technology Grant[2021B0909050003] ; Guangdong Province High-level Innovative Research Institute project[2022TD-49] ; Guangdong Province High-level Innovative Research Institute project[9183-20FC-2A00-204D-DD6P] ; Shaanxi Science and Technology
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001481206200004
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/317608]  
专题中国科学院上海药物研究所
通讯作者Wang, Wenting; Chen, Qian; Wu, Shengxi
作者单位1.Fourth Mil Med Univ, Sch Basic Med, Dept Neurobiol, Xian, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Innovat Res Inst, Xian, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China
推荐引用方式
GB/T 7714		 Qi, Chuchu,Sima, Wenqi,Mao, Honghui,et al. Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice[J]. NATURE COMMUNICATIONS,2025,16(1):18.
APA Qi, Chuchu.,Sima, Wenqi.,Mao, Honghui.,Hu, Erling.,Ge, Junye.,...&Wu, Shengxi.(2025).Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice.NATURE COMMUNICATIONS,16(1),18.
MLA Qi, Chuchu,et al."Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice".NATURE COMMUNICATIONS 16.1(2025):18.

入库方式： OAI收割

来源：上海药物研究所

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