SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation
文献类型：期刊论文
| 作者 | Chen, Liu2; Wang, Xiaoping2; Wang, Yuchen2; Yao, Qingxin1,2; Liu, Yunyao2,5; Zhu, Yongcheng2,5; Huang, He4; Yang, Hedan3; Yang, Yin3; He, Yuan2 |
| 刊名 | AGING CELL
 |
| 出版日期 | 2025-05-08 |
| 页码 | 16 |
| 关键词 | binding interaction skin aging SQSTM1/p62 USP7 |
| ISSN号 | 1474-9718 |
| DOI | 10.1111/acel.70078 |
| 通讯作者 | He, Yuan(yuanhe0822@cpu.edu.cn) ; Qiang, Lei(lqiang@cpu.edu.cn) |
| 英文摘要 | Skin aging is a complex process driven by intrinsic genetic factors and extrinsic environmental influences. In this study, sequestosome1 (SQSTM1/p62) was identified as a key regulator of senescence, the senescence-associated secretory phenotype (SASP), and skin aging. Notably, p62 expression is reduced in senescent cells and aging skin of both humans and mice. The depletion of p62 in the epidermis was found to be positively associated with accelerated aging and the initiation of SASP. Mechanistically, p62 inhibits the accumulation of ubiquitin-specific protease 7 (USP7) during senescence induction by orchestrating its degradation through specific binding interactions. In particular, the Tyr-67 residue within the PB1 domain or Gln-418 within the UBA domain of p62 forms a hydrogen bond with Ala-993 in the Ubl5 domain of USP7. Mutations in either Tyr-67 or Gln-418 of p62, or Ala-993 of USP7, resulted in the induction of cellular senescence, highlighting the critical role of these molecular interactions in the regulation of aging processes. |
| WOS关键词 | SECRETORY PHENOTYPE ; CANCER |
| 资助项目 | National Natural Science Foundation of China ; [82274156] ; [81974425] ; [82002907] |
| WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
| 语种 | 英语 |
| WOS记录号 | WOS:001483944000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317620]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | He, Yuan; Qiang, Lei |
| 作者单位 | 1.WuXi AppTec, Global Platform One Vis, Shanghai, Peoples R China 2.China Pharmaceut Univ, Sch Basic Med & Clin Pharm, State Key Lab Nat Med, Nanjing, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Hosp Dermatol, Nanjing, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 5.Chinese Acad Med Sci & Peking Union Med Coll, Jiangsu Key Lab Mol Biol Skin Dis & STIs, Inst Dermatol, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Liu,Wang, Xiaoping,Wang, Yuchen,et al. SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation[J]. AGING CELL,2025:16. |
| APA | Chen, Liu.,Wang, Xiaoping.,Wang, Yuchen.,Yao, Qingxin.,Liu, Yunyao.,...&Qiang, Lei.(2025).SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation.AGING CELL,16. |
| MLA | Chen, Liu,et al."SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation".AGING CELL (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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