Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging
文献类型：期刊论文
| 作者 | Chen, Si5,6; Chen, Hao1,6; Li, Xinxin1; He, Shuqing6; Shou, Kangquan6; Qian, Kun1; Fang, Zhao1; Gu, Feng3; Chang, Baisong2; Cheng, Zhen1,4,6 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2025-03-05 |
| 页码 | 14 |
| 关键词 | BBB disruption cerebral collateral circulation crystalline organic nanoprobe live-brain imaging NIR-II fluorescence |
| DOI | 10.1002/advs.202416390 |
| 英文摘要 | Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing the need for accurate and in vivo diagnostic tools that can afford valuable pathophysiological insight into the functioning of neurovascular unit in space and time. Currently, understanding of collateral perfusion and BBB evolution under both physiological and pathological conditions remains sparse, largely owing to limitations in methods for recording diminutive route of cerebral blood flow. Here, it is reported that highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed of small-molecule dye and bovine serum albumin showed vast potential for live-brain vascular imaging in the second near-infrared window (NIR-II, 1000-1700 nm). The 4T-BSA nanoprobes had superior imaging penetration depth in intact mouse brain with high signal-to-background ratio (SBR) of 6.0 and down to sub-50-mu m spatial resolution of cerebral vasculature in three typical models of neurological pathophysiology. By visualizing the vascular collateral perfusion and albumin leakage, 4T-BSA nanoprobes identified the pathological activities of brain associated with the arterial/venous collateral flow network and BBB disruption. It is anticipated that NIR-II imaging of cerebral collateral circulation and BBB disruption will bring broad opportunities to address major medical challenges across timely, protective, and restorative interventions for neurological diseases. |
| WOS关键词 | CEREBRAL-BLOOD-FLOW ; MOLECULE ; STROKE ; HEALTH |
| 资助项目 | National Natural Science Foundation of China ; Natural Science Fund for Distinguished Young Scholars of Hubei Province[2024AFA084] ; Shanghai Municipal Science and Technology Major Project[TM202301H003] ; [52373307] ; [U2267221] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001438023200001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316469]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chang, Baisong; Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 3.Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA 4.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Peoples R China 5.Cent South Univ, Xiangya Hosp, Dept Neurol, Xiangya Rd 88, Changsha 410008, Peoples R China 6.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Mol Imaging Program Stanford MIPS,Bio X Program, Stanford, CA 94305 USA |
| 推荐引用方式 GB/T 7714 | Chen, Si,Chen, Hao,Li, Xinxin,et al. Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging[J]. ADVANCED SCIENCE,2025:14. |
| APA | Chen, Si.,Chen, Hao.,Li, Xinxin.,He, Shuqing.,Shou, Kangquan.,...&Cheng, Zhen.(2025).Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging.ADVANCED SCIENCE,14. |
| MLA | Chen, Si,et al."Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging".ADVANCED SCIENCE (2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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