Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury
文献类型：期刊论文
| 作者 | Li, Wenjun2,3; Liu, Li2,3; Qian, Shengying2,4; Chen, Yingfen2,4; Ya, Ru2,4; Ma, Ningning2,4; Hao, Yawen2,4; Ge, Shujun2,3; Zhang, Xiaoxiao2,3; Yang, Liu1 |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
 |
| 出版日期 | 2025-04-01 |
| 卷号 | 1871期号:4页码:14 |
| 关键词 | ALD miR-320 TFRC Ferroptosis |
| ISSN号 | 0925-4439 |
| DOI | 10.1016/j.bbadis.2025.167748 |
| 英文摘要 | Alcohol-associated Liver Disease (ALD) is one of the major chronic liver diseases worldwide and has high mortality and high incidence rate. microRNA-320 (miR-320), a highly conserved and widely expressed miRNA, has been reported to be involved in lipid metabolism; however, whether miR-320 affects the progression of ALD remains unclear. In this study, we demonstrated that hepatic miR-320 was significantly downregulated in chronic-plus-binge alcohol-fed mice. Interestingly, such downregulation might accelerate ALD progression as evidenced that hepatocyte-specific miR-320 deficient mice displayed higher susceptibility to acute-on-chronic alcohol feeding-induced steatosis and inflammation. Moreover, restoration of hepatic miR-320 ameliorated acute-on-chronic alcohol-induced hepatocyte damage and steatosis. Mechanistically, miR-320 inhibited alcoholinduced ferroptosis by targeting Transferrin Receptor 1 (TFRC) to suppress iron accumulation. Moreover, silencing of Tfrc in hepatocytes attenuated ethanol-induced iron accumulation, thus inhibiting ferroptosis and ultimately mitigating ALD. Taken together, these findings suggest that miR-320 plays an important role in limiting ALD progression via inhibiting ferroptosis, providing a therapeutic target for the treatment of ALD. |
| WOS关键词 | PATHOGENESIS ; HEPCIDIN ; MIR-320 |
| 资助项目 | National Natural Science Foundation of China[82300657] ; National Natural Science Foundation of China[82270601] ; National Key Research and Development Program of China[2023YFA1800804] ; Natural Science Foundation of Shanghai[22ZR1473800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001435818400001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316478]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Liu; He, Yong |
| 作者单位 | 1.Nanjing Med Univ, Sch Basic Med Sci, Dept Pharmacol, 101 Longmian Ave, Nanjing 211166, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med SIMM, Shanghai, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wenjun,Liu, Li,Qian, Shengying,et al. Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2025,1871(4):14. |
| APA | Li, Wenjun.,Liu, Li.,Qian, Shengying.,Chen, Yingfen.,Ya, Ru.,...&He, Yong.(2025).Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1871(4),14. |
| MLA | Li, Wenjun,et al."Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1871.4(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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