Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke
文献类型：期刊论文
| 作者 | Yu, Kai1,4; Fu, Lidan5,6; Chao, Yu7; Zeng, Xiaodong8,9; Zhang, Yonggang4; Chen, Yuanyuan1,4,8,9; Gao, Jialu1,4,10; Lu, Binchun2; Zhu, Hua4; Gu, Lijuan4 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2025-03-05 |
| 卷号 | 19期号:10页码:10323-10336 |
| 关键词 | ischemic stroke small interferingRNA therapy near-infrared II imaging blood-brainbarrier deep learning |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.4c18035 |
| 英文摘要 | Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the clinical translation of siRNA-based therapies is significantly hampered by the formidable blood-brain barrier (BBB), which restricts drug penetration into the central nervous system. To address this challenge, we have developed an innovative long-circulating near-infrared II (NIR-II) nanoparticle platform YWFC NPs, which is meticulously engineered to enhance BBB transcytosis and enable efficient delivery of siRNA targeting NLRP3 (siNLRP3@YWFC NPs) in preclinical models of ischemic stroke. Furthermore, we integrated advanced deep learning neural network algorithms to optimize in vivo NIR-II imaging of the cerebral infarct penumbra, achieving an improved signal-to-background ratio at 72 h poststroke. In vivo studies employing middle cerebral artery occlusion (MCAO) mouse models demonstrated that image-guided therapy with siNLRP3@YWFC NPs, guided by prolonged NIR-II imaging, resulted in significant therapeutic benefits. |
| WOS关键词 | ENDOVASCULAR THROMBECTOMY ; IN-VIVO ; TIME ; RNA ; KNOCKING ; DELIVERY ; DYES |
| 资助项目 | National Natural Science Foundation of China[2023YFC3605502] ; National Key R&D Program of China[22477129] ; National Key R&D Program of China[82273796] ; National Key R&D Program of China[82171336] ; National Key R&D Program of China[82071339] ; National Key R&D Program of China[82271370] ; National Key R&D Program of China[82371346] ; National Key R&D Program of China[62425116] ; National Key R&D Program of China[82427807] ; National Key R&D Program of China[92359301] ; National Natural Science Foundation of China[TSQN202306320] ; Taishan Scholar Project of Shandong Province[SYS202205] ; Shandong Laboratory Program[ZR2023MB085] ; Natural Science Foundation of Shandong Province[JCYJ20240813111300001] ; Natural Science Foundation of Shandong Province[JCYJ20230807090100002] ; Natural Science Foundation of Shandong Province[JCYJ20220530140605012] ; Shenzhen Science and Technology Research Grant[2023A1515012649] ; Guangdong Basic and Applied Basic Research Foundation[JCRCFZ-2022-031] ; Wuhan University People's Hospital Cross-Innovation Talent Project |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001437927700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316487]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiong, Xiaoxing; Hu, Zhenhua; Hong, Xuechuan; Xiao, Yuling |
| 作者单位 | 1.Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China 2.Tsinghua Univ, Dept Precis Instrument, Beijing 100084, Peoples R China 3.Natl Key Lab Kidney Dis, Beijing 100853, Peoples R China 4.Wuhan Univ, Renmin Hosp, Sch Pharmaceut Sci, Dept Neurosurg,Cent Lab, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 7.Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 9.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 10.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Kai,Fu, Lidan,Chao, Yu,et al. Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke[J]. ACS NANO,2025,19(10):10323-10336. |
| APA | Yu, Kai.,Fu, Lidan.,Chao, Yu.,Zeng, Xiaodong.,Zhang, Yonggang.,...&Xiao, Yuling.(2025).Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.ACS NANO,19(10),10323-10336. |
| MLA | Yu, Kai,et al."Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke".ACS NANO 19.10(2025):10323-10336. |
入库方式： OAI收割
来源：上海药物研究所
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