Nanobody-based drug delivery systems for cancer therapy
文献类型：期刊论文
| 作者 | Liu, Lin1,4; Tu, Bin1,5; Sun, Yao1,4; Liao, Lingling1,4; Lu, Xiaoling6; Liu, Ergang1; Huang, Yongzhuo1,2,3,4,5
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| 刊名 | JOURNAL OF CONTROLLED RELEASE
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| 出版日期 | 2025-05-10 |
| 卷号 | 381页码:29 |
| 关键词 | Nanobody VHH Cancer therapy Targeted drug delivery systems Nanobody modification |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2025.02.058 |
| 英文摘要 | Targeted delivery can elevate the local drug concentration within tumor tissues, while minimizing drug distribution to normal tissues, thus enhancing the effectiveness of anti-tumor medications and reducing adverse effects and systemic toxicities. Nanobodies, the novel molecular pattern of antibodies characterized by their small size, high stability, strong specificity, and low immunogenicity, have been extensively applied in targeted drug delivery for tumor therapy. This review discusses structural disparities and functional advantages of nanobodies compared to other antibody fragments and full-length antibody. It also highlights nanobody applications in targeted tumor therapy, focusing on their use in modifying delivery systems, e.g., liposomes, EVs, micelles, albumin nanoparticles, gold nanoparticles, polymeric nanoparticles, and as nanobody-drug conjugates. This review delves into the methods applied for integrating nanobodies into different drug delivery carriers, in order to provide useful information for researchers developing nanobody-based targeted drug delivery systems. |
| WOS关键词 | SINGLE-DOMAIN ANTIBODY ; TARGETED RADIONUCLIDE THERAPY ; GROWTH-FACTOR RECEPTOR ; EXTRACELLULAR VESICLES ; POLYMERIC MICELLES ; EGFR NANOBODY ; TUMOR-CELLS ; FRAGMENTS ; PROTEIN ; NANOPARTICLES |
| 资助项目 | National Natural Science Foundation of China[82341232] ; International Partnership Program of the Chinese Academy of Sciences[083GJHZ2023021GC] ; International Partnership Program of the Chinese Academy of Sciences[083GJHZ2023012FN] ; Natural Science Foundation of Shanghai Municipal[24ZR1477500] ; CAS President's International Fellowship Initiative[2024VBB0004] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Union Project of Guangzhou University of TCM and Zhongshan Hospital of TCM[GZYZS2024D05] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; [CXTD2022011] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001437208000001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316499]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Ergang; Huang, Yongzhuo |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China 4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 5.Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Zhongshan 528400, Peoples R China 6.Guangxi Med Univ, Coll Stomatol, Nanning 530021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lin,Tu, Bin,Sun, Yao,et al. Nanobody-based drug delivery systems for cancer therapy[J]. JOURNAL OF CONTROLLED RELEASE,2025,381:29. |
| APA | Liu, Lin.,Tu, Bin.,Sun, Yao.,Liao, Lingling.,Lu, Xiaoling.,...&Huang, Yongzhuo.(2025).Nanobody-based drug delivery systems for cancer therapy.JOURNAL OF CONTROLLED RELEASE,381,29. |
| MLA | Liu, Lin,et al."Nanobody-based drug delivery systems for cancer therapy".JOURNAL OF CONTROLLED RELEASE 381(2025):29. |
入库方式： OAI收割
来源：上海药物研究所
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