Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia
文献类型：期刊论文
| 作者 | Chen, Guihua4,5,6; Yang, Chenxiao5; Xu, Xingyu5; Yang, Lu7; Zhang, Yingyan5; Cai, Chao1,2; Muhitdinov, Bahtiyor3,5,6; Turaev, Abbaskhan3; Qiu, Hong5; Huang, Shaogang4 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 357页码:15 |
| 关键词 | Trichosanthes polysaccharides Carboxymethyl chitosan Cancer cachexia Wound healing Scar hyperplasia Engrailed-1 |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2025.123378 |
| 英文摘要 | Cancer cachexia affects up to 80 % of advanced cancer patients and contributes to significant mortality. Impaired wound healing in cachectic patients limits physical activity, leads to nutrient loss, and increases infection risk. This study develops multifunctional hydrogels composed of oxidized polysaccharides (TPS) from Radix Trichosanthis and carboxymethyl chitosan (termed CMOT) to enhance wound healing and mitigate scar hyperplasia. TPS, characterized by its immunomodulatory properties, was oxidized to create aldehyde derivatives (oTPS1 and oTPS2) with varying oxidation levels and crosslinked with carboxymethyl chitosan through Schiff base reactions to form hydrogels (CMOT1 and CMOT2). It indicates the ability to tailor the rheological and mechanical properties of CMOT hydrogels through controlled oxidation and cross-linking. These hydrogels exhibited excellent self-healing properties, biocompatibility, and immunoregulatory effects on macrophages and T lymphocytes. Notably, CMOT2 hydrogel, with higher aldehyde content, exhibited superior mechanical properties, enhanced water retention, and slower degradation than CMOT1, consequently, accelerating wound healing in cancer cachexia conditions and reducing scar hyperplasia. The therapeutic mechanisms were associated with promoting angiogenesis, collagen synthesis, and epithelial repair, while down-regulating En-1. It not only addresses the challenges of wound healing in cancer cachexia but also offers a potential therapeutic strategy for scar hyperplasia inhibition. |
| WOS关键词 | PURIFICATION ; SPECTROSCOPY ; ANTIOXIDANT ; PERFORMANCE ; EXTRACTION ; REPAIR |
| 资助项目 | National Key Research and Development Program of China[2022YFE0203600] ; NSFC[82304842] ; NSFC[81925935] ; NSFC[083GJHZ2023021GC] ; NSFC[083GJHZ2023012FN] ; International Partnership Pro-gram of Chinese Academy of Sciences, Chinese Academy of Sciences President's International Fellowship Initiative[2024VBB0004] ; Department of Science and Technology of Guangdong Province (High-level Innovative Research Institute)[2021B0909050003] ; Scien-tific Research and Innovation Projects of Zhongshan City[LJ2021001] ; Scien-tific Research and Innovation Projects of Zhongshan City[CXTD2022011] ; Scien-tific Research and Innovation Projects of Zhongshan City[2023B2033] ; Scien-tific Research and Innovation Projects of Zhongshan City[cn/31129.02] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001435863600001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316502]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Qin; Wang, Huiyuan; Huang, Yongzhuo |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs Minist Educ, Qingdao 266003, Peoples R China 2.Laoshan Lab, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 3.Uzbek Acad Sci, Inst Bioorgan Chem, Lab Polysaccharide Chem, Tashkent 100125, Uzbekistan 4.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangdong Clin Res Acad Chinese Med, Artemisinin Res Ctr,Chinese Med Guangdong Lab,Heng, Guangzhou 510450, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China 7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guihua,Yang, Chenxiao,Xu, Xingyu,et al. Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia[J]. CARBOHYDRATE POLYMERS,2025,357:15. |
| APA | Chen, Guihua.,Yang, Chenxiao.,Xu, Xingyu.,Yang, Lu.,Zhang, Yingyan.,...&Huang, Yongzhuo.(2025).Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia.CARBOHYDRATE POLYMERS,357,15. |
| MLA | Chen, Guihua,et al."Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerates cachectic wound healing and reduces scar hyperplasia".CARBOHYDRATE POLYMERS 357(2025):15. |
入库方式： OAI收割
来源：上海药物研究所
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