Tailoring nanovectors for optimal neoantigen vaccine efficacy
文献类型：期刊论文
| 作者 | Zheng, Youshi2,4,5; Wang, Bing2,5; Cai, Zhixiong2,4,5; Lai, Zisen2,5; Yu, Haijun1,4,6 ; Wu, Ming2,4,5; Liu, Xiaolong2,3,4,5; Zhang, Da2,4,5
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| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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| 出版日期 | 2025-03-26 |
| 卷号 | 13期号:13页码:4045-4058 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d4tb02547d |
| 英文摘要 | The primary objective of neoantigen vaccines is to elicit a robust anti-tumor immune response by generating neoantigen-specific T cells that can eradicate tumor cells. Despite substantial advancements in personalized neoantigen prediction using next-generation sequencing, machine learning, and mass spectrometry, challenges remain in efficiently expanding neoantigen-specific T cell populations in vivo. This challenge impedes the widespread clinical application of neoantigen vaccines. Nanovector-based neoantigen delivery systems have emerged as a promising solutions to this challenge. These nanovectors offer several advantages, such as enhanced stability, targeted intracellular delivery, sustained release, and improved antigen-presenting cell (APC) activation. Notably, they effectively deliver various neoantigen vaccine formulations (DC cell-based, synthetic long peptide (SLP)-based or DNA/mRNA-based) to APCs or T cells, thereby activating both CD4+ T and CD8+ T cells. This ultimately induces a specific anti-tumor immune response. This review focuses on recent innovations in neoantigen vaccine delivery vectors. We aim to identify optimal design parameters for vectors tailored to different neoantigen vaccine types, with an emphasis on enhancing the tumor microenvironment and stimulating the production of neoantigen-specific cytotoxic T cells. By maximizing the potential of these delivery systems, we aim to accelerate the clinical translation of neoantigen nanovaccines and advance cancer immunotherapy. |
| WOS关键词 | MESSENGER-RNA VACCINES ; DELIVERY ; MUTANOME |
| 资助项目 | Natural Science Foundation of Fujian Province[62175031] ; Natural Science Foundation of Fujian Province[62275050] ; Natural Science Foundation of China[2022J06034] ; Fujian Province Outstanding Youth Science Fund Projects[2021ZQNZD013] ; Fujian Provincial Health and Middle-aged and Young Scientific Research Major Projects[2020J011154] ; Natural Science Foundation of Fujian Province[2022-S-rc5] ; Young and middle-aged talent research project of Fuzhou city[2024CXA053] ; Fujian Provincial Health and Medical Innovation Project |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001437124000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316505]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Xiaolong; Zhang, Da |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 2.Fujian Agr & Forestry Univ, Fuzhou 350002, Peoples R China 3.Chinese Acad Sci, Fujian Inst Res Struct Matter, CAS Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Peoples R China 4.Fuzhou Univ, Mengchao Medx Ctr, Fuzhou 350116, Peoples R China 5.Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Youshi,Wang, Bing,Cai, Zhixiong,et al. Tailoring nanovectors for optimal neoantigen vaccine efficacy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2025,13(13):4045-4058. |
| APA | Zheng, Youshi.,Wang, Bing.,Cai, Zhixiong.,Lai, Zisen.,Yu, Haijun.,...&Zhang, Da.(2025).Tailoring nanovectors for optimal neoantigen vaccine efficacy.JOURNAL OF MATERIALS CHEMISTRY B,13(13),4045-4058. |
| MLA | Zheng, Youshi,et al."Tailoring nanovectors for optimal neoantigen vaccine efficacy".JOURNAL OF MATERIALS CHEMISTRY B 13.13(2025):4045-4058. |
入库方式： OAI收割
来源：上海药物研究所
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