Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses
文献类型：期刊论文
| 作者 | Hu, Shulei1,3; Zhong, Qiuyu1,3; Xie, Xiong1; Zhang, Shurui1; Wang, Jinlin1; Liu, Hong1,2,3 ; Dai, Wenhao1,2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2025-07-01 |
| 卷号 | 122页码:19 |
| 关键词 | Innate immunity response SARS-CoV-2 3CLpro PLpro EV71 3Cpro 2Apro Viral protease inhibitor |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2025.130168 |
| 英文摘要 | Viral infectious diseases have been seriously affecting human life and health. SARS-CoV-2 was the pathogen that caused Coronavirus Disease 2019 (COVID-19), and the impact of COVID-19 is still existing. Enterovirus 71 (EV71) is the primary pathogen of hand, foot, and mouth disease (HFMD), and no effective direct-acting antiviral drugs targeting EV71 has been approved yet. Innate antiviral strategies play an important role in preventing virus infections depending on the powerful immune regulatory system of body, while viruses have evolved to exploit diverse methods to overcome immune response. Viral proteases, which are known in cleaving viral polyproteins, have also been found to modulate the innate immunity of host cells, thereby promoting viral proliferation. Herein, we reviewed the current development of SARS-CoV-2 3CLpro, PLpro, and EV71 3Cpro and 2Apro, mainly including structure, function, modulation of immune response, and inhibitors of these four proteases, to further deepen the understanding of viral pathogenesis and provide a new perspective for subsequent corresponding drug development. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; PAPAIN-LIKE PROTEASE ; REGULATORY FACTOR 7 ; 3C PROTEASE ; CRYSTAL-STRUCTURE ; HIV-1 PROTEASE ; 2A PROTEINASE ; MAIN PROTEASE ; I INTERFERON ; IKK-EPSILON |
| 资助项目 | National Natural Science Foundation of China[82341091] ; National Natural Science Foundation of China[22107107] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[22337003] ; National Natural Science Foundation of China[82121005] ; National Key Research and Development Program of China[2021YFC0864900] ; China Postdoctoral Science Foundation[BX202133] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001449356900001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316680]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Dai, Wenhao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 3.China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Shulei,Zhong, Qiuyu,Xie, Xiong,et al. Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2025,122:19. |
| APA | Hu, Shulei.,Zhong, Qiuyu.,Xie, Xiong.,Zhang, Shurui.,Wang, Jinlin.,...&Dai, Wenhao.(2025).Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,122,19. |
| MLA | Hu, Shulei,et al."Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 122(2025):19. |
入库方式： OAI收割
来源：上海药物研究所
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