Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice
文献类型：期刊论文
| 作者 | Zhou, Wufang2,3,4; Zhou, Jialin5; Lu, Qianyu2,3; Wang, Long3; Liang, Yutao3,6,7; Xing, Ye3,6,7; Zhang, Zheng1,3; Yang, Jinshan5; Zhao, Wenxue2; Li, Xin2 |
| 刊名 | JOURNAL OF SLEEP RESEARCH
 |
| 出版日期 | 2025-03-18 |
| 页码 | 16 |
| 关键词 | delta power spontaneous running theta wave voluntary exercise |
| ISSN号 | 0962-1105 |
| DOI | 10.1111/jsr.70023 |
| 英文摘要 | The relationship between physical activity and sleep quality is a critical area of investigation, given the importance of both behaviours for health and disease. Despite the common use of running wheels to assess circadian rhythms and exercise, their impact on sleep has not been thoroughly explored. Here, we present a detailed analysis of how voluntary running affected sleep/wakefulness duration, architecture and electrophysiological characteristics in mice. Sequential electroencephalogram (EEG) assessments revealed that voluntary running elicits a progressive alteration in sleep/wake configurations, including a reduction in overall daily sleep time and an enhancement in sleep/wakefulness consolidation. These modifications exhibited a temporal association with the intensity of running activities. The observed changes in sleep/wakefulness duration and architecture partially persist even after the discontinuation of running. Spontaneous running also gradually changed the amplitude and/or frequency of EEG theta power not only during the running phase but also in rapid eye movement sleep (REMS). In vivo endoscopic calcium imaging in freely behaving mice revealed that running and REMS were accompanied by the activation of largely shared yet distinctive neuronal cohorts within the hippocampal CA1 region, concomitant with EEG theta oscillations during both behaviours. These findings highlight the dynamic nature of sleep/wakefulness regulation in response to voluntary exercise and suggest that physical activity played a pivotal role in modulating sleep need and the daily balance between sleep and wakefulness. |
| WOS关键词 | THETA OSCILLATIONS ; HIPPOCAMPAL THETA ; EXERCISE ; NEURONS ; ADAPTATION ; PLASTICITY ; OREXIN ; CELLS ; SPEED ; POWER |
| 资助项目 | National Natural Science Foundation of China ; Shanghai Pujiang Program[21PJ1415700] ; Lingang Laboratory grant[LG-QS-202204-03] ; Basic and Applied Basic Research Foundation of Guangdong Province[2024A1515013077] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022013] ; Zhongshan Municipal Bureau of Science and Technology[2019B090904008] ; High-level Innovative Research Institute[2021B0909050003] ; Department of Science and Technology of Guangdong Province ; [82271526] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001446804800001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316683]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shi, Guangsen |
| 作者单位 | 1.Guangzhou Univ Chinese Med, Guangzhou, Peoples R China 2.Sun Yat Sen Univ, Sch Med, Shenzhen Campus, Shenzhen, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 4.Dalian Univ Technol, Dept Life & Pharmaceut Sci, Panjin, Peoples R China 5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 7.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wufang,Zhou, Jialin,Lu, Qianyu,et al. Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice[J]. JOURNAL OF SLEEP RESEARCH,2025:16. |
| APA | Zhou, Wufang.,Zhou, Jialin.,Lu, Qianyu.,Wang, Long.,Liang, Yutao.,...&Shi, Guangsen.(2025).Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice.JOURNAL OF SLEEP RESEARCH,16. |
| MLA | Zhou, Wufang,et al."Time-Dependent Regulation of Sleep-Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice".JOURNAL OF SLEEP RESEARCH (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
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