Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing
文献类型：期刊论文
| 作者 | Zhang, Xiaoru1,6; Wen, Shuiling1,6; Liu, Qin1,6; Cai, Wenli1,6; Ning, Keke1,5; Liu, Han3,4; Liu, Ergang1; Huang, Yongzhuo1,2,3,4,5,6 ; Zeng, Feng6
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| 刊名 | NANO TODAY
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| 出版日期 | 2025-06-01 |
| 卷号 | 62页码:18 |
| 关键词 | Diabetic wound Nanozymes Astragalus polysaccharide Oxidative stress Hydrogel dressing |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2025.102739 |
| 英文摘要 | Diabetic wounds (DW) are characterized by excessive oxidative stress, chronic inflammation, hypoxia, impaired angiogenesis, weakened antioxidant defenses, and disrupted collagen remodeling, all of which delay healing and compromise tissue integrity. To address these challenges, we developed a biodegradable multifunctional hydrogel dressing (Fe/Ce@APS Gel) comprised of astragalus polysaccharide (APS), polyvinyl alcohol (PVA), and borax, functionalized with multi-enzyme mimetic nanozyme iron-modified ceria nanoparticles (Fe/CeNP-PEG). This Fe/Ce@APS Gel demonstrates potent anti-inflammatory, antioxidant, oxygenation, and pro-angiogenic properties, supporting wound healing across all stages. In the initial bleeding phase, the dressing accelerates blood clotting, promoting rapid wound stabilization. During the inflammatory phage, Fe/CeNP-PEG and APS effectively reduces excess reactive oxygen species (ROS) generates oxygen, modulates macrophage polarization, and mitigates inflammatory responses. In the proliferative phase, APS enhances cell proliferation, stimulates angiogenesis, and accelerates granulation tissue formation, supporting tissue repair. Finally, in the remodeling phase, Fe/Ce@APS Gel aids in tissue architecture reconstruction, strengthening wound integrity. Mechanistically, Fe/Ce@APS Gel facilitates DW healing by inhibiting the NLRP3/NF-kappa B signaling pathway, thereby reducing inflammation. The synergistic effects of APS and Fe/CeNP-PEG underscore the potential of Fe/Ce@APS Gel as a promising therapeutic dressing for DW treatment. |
| WOS关键词 | POLYVINYL-ALCOHOL ; ANGIOGENESIS ; NANOPARTICLES ; PROTEIN |
| 资助项目 | National Natural Science Foundation of China[32371438] ; National Key Research and Development Program of China[2022YFE0203600] ; CAS President's International Fellowship Initiative[2024VBB0004] ; NSFC[81925035] ; NSFC[82341232] ; NSFC[82404549] ; NSFC[82174456] ; Second batch of social welfare and basic research projects of Zhongshan city[2023B2033] ; Department of Education of Guangdong Province[2023ZDZX2012] ; Young Talent Project of Guangzhou University of Chinese Medicine[A1-2601-24-414-110776] ; High-level Innovative Research Institute from Department of Science and Technology of Guangdong Province[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; Program of Shanghai Committee of Science and Technology[22S21902900] ; Natural Science Foundation of Shanghai Municipal[24ZR1477500] ; Chinese Academy of Sciences[083GJHZ2023012FN] ; Chinese Academy of Sciences[083GJHZ2023021GC] ; [2024YFA1210204] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001458212800001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316893]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yongzhuo; Zeng, Feng |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Zunyi Med Univ, Sch Pharm, Zunyi 563003, Peoples R China 6.Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Jichang Rd, Guangzhou 510450, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoru,Wen, Shuiling,Liu, Qin,et al. Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing[J]. NANO TODAY,2025,62:18. |
| APA | Zhang, Xiaoru.,Wen, Shuiling.,Liu, Qin.,Cai, Wenli.,Ning, Keke.,...&Zeng, Feng.(2025).Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing.NANO TODAY,62,18. |
| MLA | Zhang, Xiaoru,et al."Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing".NANO TODAY 62(2025):18. |
入库方式： OAI收割
来源：上海药物研究所
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