Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof
文献类型：期刊论文
| 作者 | Yin, Xuejian3; Zhang, Zhengxuan4; Yuan, Ziqi1; Zhu, Qiuyu3; Xu, Peng3; Yang, Cai-Guang1 ; Zhu, Dapeng2; Yu, Biao3
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2025-04-02 |
| 卷号 | 27期号:14页码:3631-3636 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5c00742 |
| 英文摘要 | A modular approach to the potent, broad-spectrum antibiotic amycolamicin and seven diastereomeric analogues is described. The synthesis features bioinspired construction of the high-carbon amycolose segment, gold(I)-catalyzed high-yielding O-glycosylation of the trans-decalin scaffold, N-glycosylation of the bromoacetylated l-valine derivative, and condition-tuned late-stage C-acylation of the tetramic acid motif. An assessment of the antibacterial properties of these synthetic molecules indicated that the correct stereochemistry is essential for the potent bioactivity of amycolamicin. |
| WOS关键词 | NATURAL-PRODUCTS ; COLEOPHOMONE-B ; KIBDELOMYCIN ; GLYCOSYLATION ; ALKYNYLBENZOATES ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[21871290] ; National Natural Science Foundation of China[22031011] ; National Natural Science Foundation of China[2022YFA1304700] ; National Natural Science Foundation of China[2023YFA1508800] ; National Key Research & Development Program of China[ZDBS-LY-SLH030] ; Key Research Program of Frontier Sciences of CAS[XDB1060000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[YSBR-095] ; CAS Project for Young Scientists in Basic Research ; Shanghai Municipal Science and Technology Major Project[20230102] ; Shanghai Jiao Tong University STAR program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001457684500001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316914]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Cai-Guang; Zhu, Dapeng; Yu, Biao |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Zhang Jiang Inst Adv Study, Inst Translat Med, Ctr Chem Glycobiol,Natl Ctr Translat Med Shanghai, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Chem Biol, Shanghai 200032, Peoples R China 4.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Xuejian,Zhang, Zhengxuan,Yuan, Ziqi,et al. Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof[J]. ORGANIC LETTERS,2025,27(14):3631-3636. |
| APA | Yin, Xuejian.,Zhang, Zhengxuan.,Yuan, Ziqi.,Zhu, Qiuyu.,Xu, Peng.,...&Yu, Biao.(2025).Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof.ORGANIC LETTERS,27(14),3631-3636. |
| MLA | Yin, Xuejian,et al."Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof".ORGANIC LETTERS 27.14(2025):3631-3636. |
入库方式： OAI收割
来源：上海药物研究所
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