Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora
文献类型：期刊论文
| 作者 | Luo, Huijuan5; Cao, Jun5; Zhang, Yujia4; Dou, Hao5; Liang, Xu1,2,3; Feng, Zheling1,2; Ye, Yang1,2 ; Gan, Lishe4; Lin, Ligen5,6
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 183页码:9 |
| 关键词 | Garcinia multiflora MPAPs PPAPs IL-1 beta NLRP3 Steatohepatitis |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106493 |
| 英文摘要 | Natural products are an important source of drug candidates against fatty liver. Herein, two previously undescribed monocyclic polyprenylated acylphloroglucinols (MPAPs, 1 and 2) and three new polycyclic polyprenylated acylphloroglucinols (PPAPs, 3-5) were isolated from the pericarps of Garcinia multiflora, and structurally elucidated by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations, together with five known PPAPs. Compounds 1 and 2 are rare dinor-MPAPs. In lipopolysaccharide (LPS)-induced RAW264.7 macrophages, compounds 1, 3 and 4 significantly suppressed nitric oxide production. Among them, compound 3 showed the best inhibitory effect with an IC50 value of 4.12 +/- 0.94 mu & Mcy;. Furthermore, compound 3 effectively reduced interleukin-1 beta secretion in LPS plus nigericin-induced THP-1 macrophages by inhibiting NLRP3 inflammasome activation. Interestingly, the conditioned medium from LPS plus nigericinstimulated THP-1 macrophages pre-treated with compound 3 attenuated lipid accumulation in oleic acid plus palmitic acid (2/1)-induced HepG2 hepatocytes. Taken together, these findings expand the chemical diversity of G. multiflora, and further demonstrate the potential of PPAPs as candidates for treating steatohepatitis. |
| WOS关键词 | STEATOSIS ; FIBROSIS |
| 资助项目 | National Natural Science Foundation of China[82073715] ; National Natural Science Foundation of China[81872754] ; Research Fund of University of Macau[MYRG2022-00177-ICMS] ; Science and Technology Development Fund, Macao SAR[FDCT 0064/2021/AGJ] ; Science and Technology Development Fund, Macao SAR[005/2023/SKL] ; Hong Kong/Macao Joint Research and Development Fund Project of Wuyi University[2022WGALH15] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001458029600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316932]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gan, Lishe; Lin, Ligen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 311402, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 6.Univ Macau, Fac Hlth Sci, Dept Pharmaceut Sci, Macau 999078, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Huijuan,Cao, Jun,Zhang, Yujia,et al. Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora[J]. FITOTERAPIA,2025,183:9. |
| APA | Luo, Huijuan.,Cao, Jun.,Zhang, Yujia.,Dou, Hao.,Liang, Xu.,...&Lin, Ligen.(2025).Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora.FITOTERAPIA,183,9. |
| MLA | Luo, Huijuan,et al."Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora".FITOTERAPIA 183(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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