Undescribed Phyllocladane-Type Diterpenoids from Callicarpa giraldii Hesse ex Rehd. and Their Anti-Neuroinflammatory Activity
文献类型：期刊论文
| 作者 | Liang, Xu5,6; Gong, Qi7; Xu, Yuting1,2; Mu, Jiaxing3,5; Tang, Chunping4,5 ; Hu, Bintao5; Ke, Changqiang5; Yao, Sheng2,4,5,7; Zhang, Haiyan7; Ye, Yang3,4,5,6
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| 刊名 | MOLECULES
 |
| 出版日期 | 2025-03-31 |
| 卷号 | 30期号:7页码:27 |
| 关键词 | |
| DOI | 10.3390/molecules30071553 |
| 英文摘要 | Callicarpa giraldii Hesse ex Rehd. is an endemic plant in China and has long been used as a traditional medicine in several provinces. Although the plant has been reported to contain flavonoids, triterpenes, and alkaloids, this study represents the first report of the isolation of phyllocladane-type diterpenoids, a relatively rare class of compounds. In this study, 18 new phyllocladane-type diterpenoids (7-24) were isolated and structurally elucidated, including eight uncommon 3,4-seco phyllocladane-type diterpenoids (15-22) and two unusual phyllocladane-type diterpene dimers (23-24), along with six known analogues (1-6). Their structures were elucidated by a comprehensive analysis of 1D and 2D NMR, IR, and HRESIMS data. The absolute configurations were determined by single crystal X-ray diffraction experiments, DFT NMR calculations, and TDDFT ECD calculations. Based on the obtained and reported spectroscopic data, we refined a rule to distinguish phyllocladane-type diterpenoids from their diastereomeric ent-kaurane-type compounds. Additionally, the isolated compounds were evaluated for their in vitro anti-neuroinflammatory activity against lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells. Compounds 5, 10, 13, 18, 19, and 20 showed moderate inhibitory activity at the concentration of 20 mu M, with compounds 5 and 13 markedly reducing the mRNA levels of the pro-inflammatory cytokines IL-1 beta, IL-6, and TNF-alpha at this concentration. |
| WOS关键词 | LEAVES ; NUDIFLORA |
| 资助项目 | Key-Area Research and Development Program of Guangdong Province ; National Key R&D Program's Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600] ; Ministry of Science and Technology of China ; National Natural Science Foundation of China[82173696] ; National Natural Science Foundation of China[82373766] ; Guangdong Basic and Applied Basic Research Foundation[2024A1515011348] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2023010] ; [2020B0303070002] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001463882100001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316971]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yao, Sheng; Ye, Yang |
| 作者单位 | 1.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Neurol & Psychiat Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Xu,Gong, Qi,Xu, Yuting,et al. Undescribed Phyllocladane-Type Diterpenoids from Callicarpa giraldii Hesse ex Rehd. and Their Anti-Neuroinflammatory Activity[J]. MOLECULES,2025,30(7):27. |
| APA | Liang, Xu.,Gong, Qi.,Xu, Yuting.,Mu, Jiaxing.,Tang, Chunping.,...&Ye, Yang.(2025).Undescribed Phyllocladane-Type Diterpenoids from Callicarpa giraldii Hesse ex Rehd. and Their Anti-Neuroinflammatory Activity.MOLECULES,30(7),27. |
| MLA | Liang, Xu,et al."Undescribed Phyllocladane-Type Diterpenoids from Callicarpa giraldii Hesse ex Rehd. and Their Anti-Neuroinflammatory Activity".MOLECULES 30.7(2025):27. |
入库方式： OAI收割
来源：上海药物研究所
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