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Periplosides Extract from Cortex periplocae Improve Collagen Antibody-Induced Arthritis by Regulating Macrophage Polarization

文献类型：期刊论文

作者Wang, Que2; Xiong, Xiaoyu3; Chen, Li3; Zhu, Fenghua3; Yang, Xiaoqian3; Zhao, Weimin1; He, Shijun4; Zuo, Jianping2,3; Lin, Zemin2,3
刊名CURRENT ISSUES IN MOLECULAR BIOLOGY
出版日期2024-12-01
卷号46期号:12页码:14095-14105
关键词rheumatoid arthritis Cortex periplocae pregnane glycosides anti-arthritic activity collagen antibody-induced arthritis macrophage polarization
DOI10.3390/cimb46120843
文献子类Article
英文摘要Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized primarily by the synovial infiltration of inflammatory cells. Macrophage infiltration in the joint synovium is one of the early hallmarks of RA disease activity. Cortex periplocae, which has been widely employed in traditional Chinese medicine (TCM) to alleviate RA, harbors a bioactive compound known as Periploca sepium periplosides (PePs). In this study, collagen antibody-induced arthritis (CAIA) was established in mice through the administration of collagen antibodies and lipopolysaccharide (LPS), followed by treatment with PePs. The therapeutic effects of PePs were evaluated by measuring paw thickness, clinical arthritis scores, and histological changes in joint tissues. Flow cytometry and qRT-PCR were used to assess macrophage polarization in vivo and in vitro. The findings indicate that PePs effectively attenuated CAIA by suppressing the polarization of RAW264.7 cells towards the M1 phenotype while promoting their polarization towards the M2 phenotype. These results provide valuable insights into the scientific significance of PePs as a potential therapeutic agent for RA.
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:001383809000001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/317001]  
专题新药研究国家重点实验室
通讯作者Zuo, Jianping; Lin, Zemin
作者单位1.Chinese Acad Sci, Shanghai Inst Materia Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China;
2.Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Materia Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Que,Xiong, Xiaoyu,Chen, Li,et al. Periplosides Extract from Cortex periplocae Improve Collagen Antibody-Induced Arthritis by Regulating Macrophage Polarization[J]. CURRENT ISSUES IN MOLECULAR BIOLOGY,2024,46(12):14095-14105.
APA Wang, Que.,Xiong, Xiaoyu.,Chen, Li.,Zhu, Fenghua.,Yang, Xiaoqian.,...&Lin, Zemin.(2024).Periplosides Extract from Cortex periplocae Improve Collagen Antibody-Induced Arthritis by Regulating Macrophage Polarization.CURRENT ISSUES IN MOLECULAR BIOLOGY,46(12),14095-14105.
MLA Wang, Que,et al."Periplosides Extract from Cortex periplocae Improve Collagen Antibody-Induced Arthritis by Regulating Macrophage Polarization".CURRENT ISSUES IN MOLECULAR BIOLOGY 46.12(2024):14095-14105.

入库方式： OAI收割

来源：上海药物研究所

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