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Rational strategies for improving the efficiency of design and discovery of nanomedicines

文献类型：期刊论文

作者Shan, Xiaoting3,4,6; Cai, Ying2,3,4,6; Zhu, Binyu3,4,6; Zhou, Lingli4,6; Sun, Xujie3,4,6; Xu, Xiaoxuan3,4,6; Yin, Qi3,4,6; Wang, Dangge1; Li, Yaping2,3,4,5,6
刊名NATURE COMMUNICATIONS
出版日期2024-11-18
卷号15期号:1页码:9990
DOI10.1038/s41467-024-54265-3
文献子类Review
英文摘要The rise of rational strategies in nanomedicine development, such as high-throughput methods and computer-aided techniques, has led to a shift in the design and discovery patterns of nanomedicines from a trial-and-error mode to a rational mode. This transition facilitates the enhancement of efficiency in the preclinical discovery pipeline of nanomaterials, particularly in improving the hit rate of nanomaterials and the optimization efficiency of promising candidates. Herein, we describe a directed evolution mode of nanomedicines driven by data to accelerate the discovery of nanomaterials with high delivery efficiency. Computer-aided design strategies are introduced in detail as one of the cutting-edge directions for the development of nanomedicines. Ultimately, we look forward to expanding the tools for the rational design and discovery of nanomaterials using multidisciplinary approaches. Rational design strategies may potentially boost the delivery efficiency of next-generation nanomedicines. The rise of high-throughput methods and computer-aided techniques has led to a shift in the design and discovery patterns of nanomedicines to a data-driven and rational mode. In this perspective, the authors describe a directed evolution mode of nanomedicines driven by data to accelerate the discovery of nanomaterials with high delivery efficiency.
WOS关键词PROTEIN ; NANOPARTICLES
WOS研究方向Multidisciplinary Sciences
语种英语
WOS记录号WOS:001359289300028
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/317002]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 201260, Peoples R China;
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China;
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Shan, Xiaoting,Cai, Ying,Zhu, Binyu,et al. Rational strategies for improving the efficiency of design and discovery of nanomedicines[J]. NATURE COMMUNICATIONS,2024,15(1):9990.
APA Shan, Xiaoting.,Cai, Ying.,Zhu, Binyu.,Zhou, Lingli.,Sun, Xujie.,...&Li, Yaping.(2024).Rational strategies for improving the efficiency of design and discovery of nanomedicines.NATURE COMMUNICATIONS,15(1),9990.
MLA Shan, Xiaoting,et al."Rational strategies for improving the efficiency of design and discovery of nanomedicines".NATURE COMMUNICATIONS 15.1(2024):9990.

入库方式： OAI收割

来源：上海药物研究所

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