Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies
文献类型：期刊论文
| 作者 | Chen, Luojia1; Chen, Si-Ling1; Yuan, Yuncong1; Leng, Xiang1; Xu, Xiaoyu1; Chen, Jingyuan1; Shi, Jiayi1; Qian, Kun2; Xie, Yuanlong1; Ding, Qihang1,3 |
| 刊名 | AGGREGATE
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 5期号:6 |
| 关键词 | aggregation-induced emission near infrared phototheranostics small molecules tumor microenvironment |
| DOI | 10.1002/agt2.657 |
| 文献子类 | Review |
| 英文摘要 | Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies for constructing phototheranostic systems by engineering the integration of photosensitizers (PSs) into nanosystems, nano-PSs face challenges including complexity in the preparation process, low delivery efficiency, and potential toxicity issues. Contrastingly, the burgeoning popularity of small molecule PSs characterized by aggregation-induced emission (AIE) has become evident in the arena of cancer phototheranostics. This preference is underscored by their well-defined structures, adjustable photophysical properties, and low toxicity. Therefore, acquiring profound insights into the pioneering strides achievable through a solitary small molecule PS with AIE in tumor phototheranostics is of paramount scientific significance. In this review, we will discuss the recent progress of small molecule PSs with AIE properties in cancer diagnosis and phototherapies with representative examples, guided by the ethos of Complexity made easy. We also look forward to the future development direction of AIE small molecules, with a central objective of advancing cancer research through a focal emphasis on simplicity, expeditiousness, and safety.Small molecule photosensitizers (PSs) with aggregation-induced emission (AIE) are gaining biomedical popularity due to their clear structures, tunable photophysical properties, and low toxicity. This review highlights the recent progress of AIE small molecules in cancer diagnosis and phototherapies, guided by the ethos of Complexity made easy. We look forward to the future development of AIE small molecules, with an objective of advancing cancer research through a focal emphasis on simplicity, expeditiousness, and safety. image |
| WOS关键词 | FATTY-ACID SYNTHASE ; PHOTODYNAMIC ABLATION ; NATURAL-PRODUCTS ; LIPID DROPLETS ; FLUORESCENCE ; CELLS ; MITOCHONDRIA ; CHEMOTHERAPY ; CLEAVAGE ; THERAPY |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001302603100001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317012]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Yuanlong; Ding, Qihang; Cheng, Zhen; Gu, Meijia |
| 作者单位 | 1.Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Spine Surg & Musculoskeletal Tumor,Minist Edu, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Korea Univ, Dept Chem, Seoul 02841, South Korea 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Luojia,Chen, Si-Ling,Yuan, Yuncong,et al. Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies[J]. AGGREGATE,2024,5(6). |
| APA | Chen, Luojia.,Chen, Si-Ling.,Yuan, Yuncong.,Leng, Xiang.,Xu, Xiaoyu.,...&Gu, Meijia.(2024).Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies.AGGREGATE,5(6). |
| MLA | Chen, Luojia,et al."Complexity made easy: Aggregation-induced emission small molecules for cancer diagnosis and phototherapies".AGGREGATE 5.6(2024). |
入库方式： OAI收割
来源：上海药物研究所
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