Recent advances in mitochondria-targeting theranostic agents
文献类型：期刊论文
| 作者 | Qian, Kun1; Gao, Shu1,2; Jiang, Zhaoning1,2,3; Ding, Qihang4; Cheng, Zhen1,2,3 |
| 刊名 | EXPLORATION
 |
| 出版日期 | 2024-08-01 |
| 卷号 | 4期号:4页码:20230063 |
| 关键词 | disease treatment medical imaging mitochondria-targeting theranostic agents |
| DOI | 10.1002/EXP.20230063 |
| 文献子类 | Review |
| 英文摘要 | For its vital role in maintaining cellular activity and survival, mitochondrion is highly involved in various diseases, and several strategies to target mitochondria have been developed for specific imaging and treatment. Among these approaches, theranostic may realize both diagnosis and therapy with one integrated material, benefiting the simplification of treatment process and candidate drug evaluation. A variety of mitochondria-targeting theranostic agents have been designed based on the differential structure and composition of mitochondria, which enable more precise localization within cellular mitochondria at disease sites, facilitating the unveiling of pathological information while concurrently performing therapeutic interventions. Here, progress of mitochondria-targeting theranostic materials reported in recent years along with background information on mitochondria-targeting and therapy have been briefly summarized, determining to deliver updated status and design ideas in this field to readers.Possessing diagnostic imaging and therapeutic functions, mitochondria-targeted theranostic agents can significantly optimize the treatment process and promote precision medicine. This review summarizes the research progress on these agents and the commonly used diagnostic modalities and therapeutic strategies. It also discusses various therapeutic agent categories and their disease applications, addressing unresolved issues and envisioning future directions in the field. image |
| WOS关键词 | PHOTODYNAMIC THERAPY ; GLUCOSE-METABOLISM ; SURGICAL RESECTION ; CANCER METABOLISM ; SMALL-MOLECULE ; DELIVERY ; FLUORESCENCE ; DESIGN ; FLUOROPHORES ; ONCOGENES |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001295857900011 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317021]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai, Shandong, Peoples R China 4.Korea Univ, Dept Chem, Seoul, South Korea |
| 推荐引用方式 GB/T 7714 | Qian, Kun,Gao, Shu,Jiang, Zhaoning,et al. Recent advances in mitochondria-targeting theranostic agents[J]. EXPLORATION,2024,4(4):20230063. |
| APA | Qian, Kun,Gao, Shu,Jiang, Zhaoning,Ding, Qihang,&Cheng, Zhen.(2024).Recent advances in mitochondria-targeting theranostic agents.EXPLORATION,4(4),20230063. |
| MLA | Qian, Kun,et al."Recent advances in mitochondria-targeting theranostic agents".EXPLORATION 4.4(2024):20230063. |
入库方式： OAI收割
来源：上海药物研究所
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