Euodiae Fructus (Wuzhuyu): Exploring traditional Chinese medicine compatibility for reducing toxicity
文献类型：期刊论文
| 作者 | He N(何宁)2; Ma ZZ(马珍珍)1; Wang QY(王秋月)1; Wang T(王婷)2; Yuan JY(袁佳烨)1; Yang JL(杨军令)1,2 ; Li C(李川)1,2,3,4
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| 刊名 | 中草药
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| 出版日期 | 2024-03-19 |
| 卷号 | 55期号:6页码:1812-1838 |
| 关键词 | 有毒中药 吴茱萸 吴茱萸碱 吴茱萸次碱 减毒配伍 |
| 其他题名 | 有毒中药吴茱萸及减毒配伍研究探讨 |
| 文献子类 | Article |
| 英文摘要 | Toxic traditional Chinese medicines (TCMs) are important components of clinical medications. The understanding of the toxicity associated with toxic TCMs has steadily improved. To ensure their safe use, various methods have been developed, including processing to reduce toxicity, compatibility adjustments to reduce toxicity, medication based on syndrome differentiation, as well as control of dosage size and duration. Wuzhuyu (Euodiae Fructus) is a commonly used TCM with low toxicity. It is frequently employed to alleviate pain associated with liver cold and qi stagnation, as well as to relieve diarrhea caused by spleen-stomach weakness. Modern pharmacological studies have demonstrated the anti-inflammatory, antitumor, and cardioprotective effects of Euodiae Fructus. However, Euodiae Fructus has been acknowledged as a toxic TCM in numerous classical medical texts from ancient time and has been substantiated as hepatotoxic by contemporary studies. To ensure the continued safe use of Euodiae Fructus, it is crucial to have a comprehensive understanding of the TCM toxicity and its associated detoxification measures. This review article provides an overview of the chemical composition, pharmacodynamics, adverse reactions and toxicity, and pharmacokinetics of Euodiae Fructus. Additionally, the potential reduction of the TCM toxicity through TCM compatibility is also discussed. For those toxic TCMs that exhibit prominent therapeutic effects, have well-defined toxic effects, and whose toxicity can be mitigated or alleviated through certain methods, thorough research should be conducted to establish the technical conditions for their safe clinical use and enable their continued application in clinical treatment. This could potentially expand the range of therapeutic options available in TCM. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:7683678 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317025]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang JL(杨军令); Li C(李川) |
| 作者单位 | 1.天津中医药大学 2.中国科学院上海药物研究所原创新药研究全国重点实验室 3.中科中山药物创新研究院 4.现代中医药海河实验室 |
| 推荐引用方式 GB/T 7714 | He N,Ma ZZ,Wang QY,et al. Euodiae Fructus (Wuzhuyu): Exploring traditional Chinese medicine compatibility for reducing toxicity[J]. 中草药,2024,55(6):1812-1838. |
| APA | He N.,Ma ZZ.,Wang QY.,Wang T.,Yuan JY.,...&Li C.(2024).Euodiae Fructus (Wuzhuyu): Exploring traditional Chinese medicine compatibility for reducing toxicity.中草药,55(6),1812-1838. |
| MLA | He N,et al."Euodiae Fructus (Wuzhuyu): Exploring traditional Chinese medicine compatibility for reducing toxicity".中草药 55.6(2024):1812-1838. |
入库方式： OAI收割
来源：上海药物研究所
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