Research progress of cGAS-STING signaling pathway modulators in immunotherapy
文献类型：期刊论文
| 作者 | Lou FN(娄方宁)1; Zheng MY(郑明月)2 ; Chen KX(陈凯先)1,2; Zhang SL(张素林)2
|
| 刊名 | 中国药科大学学报
 |
| 出版日期 | 2024-01-11 |
| 卷号 | 55期号:1页码:15-25 |
| 关键词 | cGAS-STING信号通路 STING激动剂 cGAS抑制剂 STING抑制剂 免疫治疗 |
| 其他题名 | cGAS-STING信号通路调节剂在免疫治疗中的研究进展 |
| 文献子类 | Review |
| 英文摘要 | Upon monitoring cytoplasmic aberrant double-stranded DNA,cGAS-STING signaling pathway induces the expression of type I interferons and pro-inflammatory cytokines,which activates the host immune response and enhances anti-tumor immune response and resistance to pathogen infection.However,sustained activation of the cGAS-STING signaling pathway drives diseases such as autoimmune diseases,aging-associated inflammation,and neurodegenerative pathologies.Herein,we describe the mechanism by which cGAS-STING signaling pathway participates in regulating the development of various immune-related diseases,with a particular review of the research and development progress of STING agonists,cGAS inhibitors,and STING inhibitors,aiming to provide some theoretical reference for the future development of cGAS-STING modulators. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:7674588 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317026]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen KX(陈凯先); Zhang SL(张素林) |
| 作者单位 | 1.中国药科大学药学院 2.中国科学院上海药物研究所,原创新药研究全国重点实验室,药物发现与设计中心 |
| 推荐引用方式 GB/T 7714 | Lou FN,Zheng MY,Chen KX,et al. Research progress of cGAS-STING signaling pathway modulators in immunotherapy[J]. 中国药科大学学报,2024,55(1):15-25. |
| APA | Lou FN,Zheng MY,Chen KX,&Zhang SL.(2024).Research progress of cGAS-STING signaling pathway modulators in immunotherapy.中国药科大学学报,55(1),15-25. |
| MLA | Lou FN,et al."Research progress of cGAS-STING signaling pathway modulators in immunotherapy".中国药科大学学报 55.1(2024):15-25. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。