Structural research and functional intervention of Caseinolytic protease P
文献类型：期刊论文
| 作者 | Wang PY(王蓬宇)1,2; Zhang T(张涛)2; Yang CG(杨财广)1,2,3
|
| 刊名 | 中国科学. 化学
 |
| 出版日期 | 2024-04-18 |
| 卷号 | 54期号:5页码:703-715 |
| 关键词 | 酪蛋白水解酶ClpP 分子识别 化学干预 抗菌 抗肿瘤 |
| 其他题名 | 酪蛋白水解酶ClpP的结构研究与功能干预 |
| 文献子类 | Article |
| 英文摘要 | Caseinolytic protease P (ClpP) is a highly conserved serine proteolytic enzyme,typically forming complexes with the AAA+ superfamily ATPases as chaperone proteins to regulate protein homeostasis within cells.Chemical intervention of the biological function of ClpP protease,especially the development of small-molecule agonists on ClpP protease,has been demonstrated as effective strategies for the treatment of a variety of diseases.In recent years,our group has made significant progress on ClpP protease in structural biology and chemical biology.On one hand,we employed structural biology methods to elucidate the crystal structures of Staphylococcus aureus ClpP (SaClpP) in three different conformations.Additionally,a gain-of-function mutant of SaClpP has been identified,which enhanced the understanding of the mechanism on ClpP activation.On the other hand,our group has undertaken the research on chemical intervention of pathogenic bacteria and human mitochondrial ClpP by small molecule agonists.We have developed small-molecule ClpP agonists with diverse structural scaffolds,and achieved selective activation of ClpP protease function across different species.These advances have promoted the ClpP-targeted antibacterial and antitumor research. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:7775028 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317028]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang CG(杨财广) |
| 作者单位 | 1.国科大杭州高等研究院药物科学与技术学院 2.中国科学院上海药物研究所新药研究国家重点实验室 3.中科环渤海(烟台)药物高等研究院 |
| 推荐引用方式 GB/T 7714 | Wang PY,Zhang T,Yang CG. Structural research and functional intervention of Caseinolytic protease P[J]. 中国科学. 化学,2024,54(5):703-715. |
| APA | Wang PY,Zhang T,&Yang CG.(2024).Structural research and functional intervention of Caseinolytic protease P.中国科学. 化学,54(5),703-715. |
| MLA | Wang PY,et al."Structural research and functional intervention of Caseinolytic protease P".中国科学. 化学 54.5(2024):703-715. |
入库方式： OAI收割
来源：上海药物研究所
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