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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold

文献类型：期刊论文

作者Lin, Junzhen2; Xiao, Fuling1,2,6; Han, Sheng2; Hu, Youhong2,3,4,5,6; Zuo, Jianping1,2,6; Tong, Xiankun1,2,6; Chen, Wuhong2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2025-08-01
卷号123页码:4
关键词Ebola virus entry inhibitor Tetrahydroisoquinoline
ISSN号0960-894X
DOI10.1016/j.bmcl.2025.130230
英文摘要Novel Ebola entry inhibitors were designed and synthesized based on decahydroisoquinolines by streamlining non-essential functional groups that do not compromise activity. All novel derivatives were evaluated for their anti-Ebola activities and cytotoxicitiies in a defective Ebola virus model. A novel tetrahydroisoquinoline Ebola virus entry inhibitor, Hu7, was readily available with antiviral activity comparable to previous findings, while demonstrating a marked reduction in toxicity. Such new compounds with simple and easy-to-synthesize structures could be potential leads for further optimizing the development of anti-Ebola drugs.
资助项目National Natural Science Foundation of P. R. China[22107108] ; Shanghai institute of materia medica,Chinese Academy of Sciences[SIMM2003ZZ-01] ; Shanghai institute of materia medica,Chinese Academy of Sciences[SIMM010108]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:001469128900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/317494]  
专题新药研究国家重点实验室
通讯作者Han, Sheng; Tong, Xiankun; Chen, Wuhong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Immunol Dis Res Ctr, 555 ZuChongZhi Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 ZuChongZhi Rd, Shanghai 201203, Peoples R China
3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, 1st Xiangshan Branch Alley, Hangzhou 310024, Peoples R China
5.Nanjing Univ Chinese Med, Coll Pharm, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Peoples R China
6.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Junzhen,Xiao, Fuling,Han, Sheng,et al. Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2025,123:4.
APA Lin, Junzhen.,Xiao, Fuling.,Han, Sheng.,Hu, Youhong.,Zuo, Jianping.,...&Chen, Wuhong.(2025).Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,123,4.
MLA Lin, Junzhen,et al."Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 123(2025):4.

入库方式： OAI收割

来源：上海药物研究所

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