Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents
文献类型：期刊论文
| 作者 | Zhu, Ziwei1,3; Li, Huilin1,3; Zhu, Wenya1,3; Du, Shaoqing1,3; Yang, Zhaokai1,3; Ren, Jianing1,3; Xu, Zhijian2 ; Duan, Hongxia1,3
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2025-04-30 |
| 卷号 | 73期号:19页码:11998-12013 |
| 关键词 | odorant-binding proteins jasmone derivatives rational design aphid repellents insect behaviorregulators |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.4c12336 |
| 英文摘要 | Odorant-binding proteins (OBPs) are potential targets for the discovery of insect behavior regulators. Cis-jasmone (CJ) was first identified as a repellent against Acyrthosiphon pisum (A. pisum) by its binding to ApisOBP3 and ApisOBP7. Therefore, twenty-one novel CJ derivatives were designed and synthesized based on the binding pockets of these two ApisOBPs. Almost all derivatives showed better binding affinities to ApisOBPs and aphid-repellent activities than CJ, respectively. The representative derivative 6bg had the most significant binding affinities to ApisOBP3 and ApisOBP7 with K i values of 6.95 mu M and 4.81 mu M, respectively. Moreover, 6bg had the highest repellent rate of 71.62% against A.pisum at a dose of 5 mu g and also elicited a dose-dependent electroantennography response. The binding mechanism revealed that hydrophobic interactions generated by nonpolar residues in ApisOBP3 and ApisOBP7 were key to the binding. This study offers insights into the rational design of novel aphid repellents targeting two OBPs. |
| WOS关键词 | RATIONAL DESIGN ; ALARM PHEROMONE ; CIS-JASMONE ; IDENTIFICATION ; ANALOGS |
| 资助项目 | National Natural Science Foundation[32172445] ; National Natural Science Foundation[31772207] |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001480011700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317584]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Duan, Hongxia |
| 作者单位 | 1.China Agr Univ, Coll Sci, Innovat Ctr Pesticide Res, Dept Appl Chem, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Key Lab Natl Forestry & Grassland Adm Pest Chem Co, Beijing 100193, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Ziwei,Li, Huilin,Zhu, Wenya,et al. Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2025,73(19):11998-12013. |
| APA | Zhu, Ziwei.,Li, Huilin.,Zhu, Wenya.,Du, Shaoqing.,Yang, Zhaokai.,...&Duan, Hongxia.(2025).Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,73(19),11998-12013. |
| MLA | Zhu, Ziwei,et al."Targeting Two Odorant-Binding Proteins in Acyrthosiphon pisum: Discovery of Novel Jasmone Derivatives as Aphid Repellents".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73.19(2025):11998-12013. |
入库方式： OAI收割
来源：上海药物研究所
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