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A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy

文献类型：期刊论文

作者Wang, Guanru6,7,8; Guo, Hao5; Wei, Mengxin4; Wang, Ying3; Jin, Zengcai3; Zhou, Jing3; He, Jun8; Li, Yaping1,2,4,6,7
刊名NANO LETTERS
出版日期2025-05-06
卷号25期号:19页码:7989-7997
关键词glioblastoma chemotherapy drug delivery tumor-specific drugaccumulation tumor-suppressiveeffects
ISSN号1530-6984
DOI10.1021/acs.nanolett.5c01609
英文摘要Chemotherapy for glioblastoma (GBM) has not achieved the desired outcome due to inefficient blood-brain barrier (BBB) penetration and limited tumor-specific drug accumulation. Strategies that employ bioinspired nanoparticles to enhance targeted drug accumulation can help improve therapeutic efficacy. In this work, a novel nanoparticle, PCM@TMA-lip, exhibiting hybrid-targeting capabilities, is presented, with an engineered cell membrane coated on a lipid core. The membrane modified with a biologically derived peptide enables PCM@TMA-lip to evade immune clearance and enable precise tumor targeting. The lipid core with docosahexaenoic acid (DHA)-conjugated Temozolomide (TMZ) enhances FABP7-mediated uptake, promotes lysosomal escape via lipid peroxidation, and reduces tumor migration and drug resistance. In vitro, PCM@TMA-lip inhibited tumor cell malignancy and suppressed the growth of 3D spheroids. In vivo, it suppressed tumor progression, reduced Ki67+ proliferation, increased TUNEL+ apoptosis, and prolonged survival in GBM-bearing mice, highlighting its potential as an effective strategy to improve GBM chemotherapy.
WOS关键词DOXORUBICIN DELIVERY ; ACID ; MEMBRANE
资助项目National Key R&D Program of China[2022YFC3401404] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; National Natural Science Foundation of China[82274498] ; Special fund for Science and Technology Innovation Teams of Shanxi Province[202304051001046] ; Special fund for Science and Technology Innovation Teams of the Administration of TCM of Shanxi Province[zyytd2024007] ; Shandong Laboratory Program[SYS202205] ; Science and Technology Commission of Shanghai Municipality[23S41900200] ; Science and Technology Commission of Shanghai Municipality[23J21900600]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001482432000001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/317614]  
专题新药研究国家重点实验室
通讯作者Zhou, Jing; He, Jun; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
3.Shanxi Prov Hosp Tradit Chinese Med, Shanxi Prov Acad Tradit Chinese Med, Dept Oncol, Taiyuan 030012, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
5.Shanxi Prov Peoples Hosp, Dept Anesthesiol, Taiyuan 030000, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
7.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.China State Inst Pharmaceut Ind, Natl Adv Med Engn Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Guanru,Guo, Hao,Wei, Mengxin,et al. A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy[J]. NANO LETTERS,2025,25(19):7989-7997.
APA Wang, Guanru.,Guo, Hao.,Wei, Mengxin.,Wang, Ying.,Jin, Zengcai.,...&Li, Yaping.(2025).A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy.NANO LETTERS,25(19),7989-7997.
MLA Wang, Guanru,et al."A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy".NANO LETTERS 25.19(2025):7989-7997.

入库方式： OAI收割

来源：上海药物研究所

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