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Research on the effects and related mechanisms of geomagnetic storm on depression

文献类型：期刊论文

作者Wu, Hui1,2,4; Yang, Yuan2; Chang, Weiyu2; Chen, Xinli2; Yang, Shiqi2; Xu, Min2; Liu, Keyu2; Yun, Yu1; Dong L(董亮)3
刊名BRAIN RESEARCH BULLETIN
出版日期2025-06-15
卷号226
关键词Depression Geomagnetic storms Melatonin
ISSN号0361-9230
DOI10.1016/j.brainresbull.2025.111369
产权排序第3完成单位
文献子类Article
英文摘要Objective: Depression has become disabling disease in the world. Geomagnetic storm is closely related to depression behavior, and melatonin is an important factor in the pathogenesis of depression. This study observed the effects of different intensities of geomagnetic storm on melatonin in depressed rats. Aim to provides a theoretical basis for the prevention and treatment of depression and other melatonin related mental illnesses during geomagnetic storms. Methods: In this study, rats with chronic unpredictable mild stress (CUMS) were exposed to geomagnetic storms of different intensities for 7 days. The depressive behavior of CUMS rats was determined via the weigh, sucrose preference test, elevated plus maze test, novelty-suppressed feeding test and open field test. Then, through the use of kits, qPCR analysis, immunofluorescence staining and western blot analysis of melatonin synthesis, melatonin metabolism and melatonin receptor pathway related indicators. Performed to explore the effects of different intensities of geomagnetism on CUMS rats and the related molecular mechanisms. Results: The reults showed moderate geomagnetic storms (50 nT) protected against depressive behaviors in CUMS rats by increasing melatonin synthesis and metabolism and MT1 receptor pathway activity, while a extreme geomagnetic storms (500 nT) and shielding from geomagnetic storms (0 nT) inhibited melatonin synthesis and metabolism and the MT1 receptor pathway and aggravated injury. Conclusions: In this study we found moderate geomagnetic storms (50 nT) protected against depressive behaviors in CUMS rats, while a extreme geomagnetic storms (500 nT) and shielding from geomagnetic storms (0 nT) aggravated injury.
学科主题地球科学 ; 空间物理学 ; 基础医学 ; 医学心理学
URL标识查看原文
出版地THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
资助项目National Natural Science Foundation of China[41964007]; Young and middle-aged academic and technical leaders reserve talent program[202305AC160016]; First affiliated hospital of Kunming medical university Doctoral foundation[2022BS004]; State key laboratory of neurology and oncology drug development general program[SKLSIM-F-2024037]; First-Class Discipline Team of Kunming Medical University[2024XKTDTS12]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001496602900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China[41964007] ; Young and middle-aged academic and technical leaders reserve talent program[202305AC160016] ; First affiliated hospital of Kunming medical university Doctoral foundation[2022BS004] ; State key laboratory of neurology and oncology drug development general program[SKLSIM-F-2024037] ; First-Class Discipline Team of Kunming Medical University[2024XKTDTS12]
版本出版稿
源URL[http://ir.ynao.ac.cn/handle/114a53/28315]  
专题云南天文台_射电天文研究组
作者单位1.The Department of Pharmacology, School of Basic Medicine, Kunming Medical University, Kunming, China;
2.Clinical Pharmacy Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China;
3.Yunnan Observatories, Chinese Academy of Sciences, Kunming, China;
4.State Key Laboratory of Neurology and Oncology Drug Development, China
推荐引用方式
GB/T 7714		 Wu, Hui,Yang, Yuan,Chang, Weiyu,et al. Research on the effects and related mechanisms of geomagnetic storm on depression[J]. BRAIN RESEARCH BULLETIN,2025,226.
APA Wu, Hui.,Yang, Yuan.,Chang, Weiyu.,Chen, Xinli.,Yang, Shiqi.,...&董亮.(2025).Research on the effects and related mechanisms of geomagnetic storm on depression.BRAIN RESEARCH BULLETIN,226.
MLA Wu, Hui,et al."Research on the effects and related mechanisms of geomagnetic storm on depression".BRAIN RESEARCH BULLETIN 226(2025).

入库方式： OAI收割

来源：云南天文台

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