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Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation

文献类型：期刊论文

作者Lu, Yan1; Chen, Cheng1; Li HY(李航宇)2,3; Zhao, Peng1; Zhao, Yuanfeng1; Li, Bohan1; Zhou, Wei1; Fan, Gaofeng1; Guan DS(关东石)2,3; Zheng, Yijun1
刊名NATURE COMMUNICATIONS
出版日期2025-02-01
卷号16期号:1
关键词Biomaterials - cells Gels and hydrogels
DOI10.1038/s41467-024-54880-0
英文摘要Viscoelastic heterogeneity of matrices plays a pivotal role in cancer cell spreading, migration, and metastasis. However, the creation of viscoelastic platforms with spatial-temporal regulation is hindered by cytotoxicity and short regulation durations. Our research presents a dual mechanism for stress relaxation regulation- both intrinsic and responsive- by incorporating Schiff base bonds and a visible light-responsive thiuram disulfide (TDS) moiety into the hydrogel. Modifying base bonds facilitates a broad spectrum of intrinsic stress relaxation times. At the same time, incorporating the visible light-responsive TDS moiety endows the hydrogel with responsive viscoelastic properties. These properties are characterized by minimal cytotoxicity, spatial-temporal controllability, dose dependency, and reversibility. Utilizing this platform, we demonstrate that ovarian cancer cells exhibit contrasting behaviors in contraction and spreading when subjected to dynamic stress relaxation changes over various time periods. Additionally, we observed a "memory effect" in the cell's response to alterations in stress relaxation time. We can spatially direct cell migration through viscoelastic heterogeneity, achieved via photopatterning substrates and laser spots. This innovative approach provides a means to regulate the viscoelasticity of hydrogels across a wide range of timescales, thereby opening avenues for more advanced studies into how cells interpret and respond to spatiotemporal viscoelastic signals.
分类号一类
WOS研究方向Multidisciplinary Sciences ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:001414689800002
资助机构This work was supported by the National Natural Science Foundation of China (Grant No. 52073175, 52473115), the National Natural Science Foundation of Shanghai (23ZR1442700), ShanghaiTech University, the Strategic Priority Research Program of Chinese Academy of Sciences, Grant No. XDB0620102, NSFC under Grant No.12372267 and National Key R&D Program of China No. 2021YFA0719302. The authors thank the support from the Analytical Instrumentation Center (contract no. SPST-AIC10112914), SPST.
其他责任者关东石，Zheng, Yijun
源URL[http://dspace.imech.ac.cn/handle/311007/101432]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.ShanghaiTech University;
2.Institute of Mechanics, CAS;
3.University of Chinese Academy of Sciences, CAS;
4.ShanghaiTech University
推荐引用方式
GB/T 7714		 Lu, Yan,Chen, Cheng,Li HY,et al. Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation[J]. NATURE COMMUNICATIONS,2025,16(1).
APA Lu, Yan.,Chen, Cheng.,李航宇.,Zhao, Peng.,Zhao, Yuanfeng.,...&Zheng, Yijun.(2025).Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation.NATURE COMMUNICATIONS,16(1).
MLA Lu, Yan,et al."Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation".NATURE COMMUNICATIONS 16.1(2025).

入库方式： OAI收割

来源：力学研究所

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