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Cavity oscillation drives pattern formation in early mammalian embryos

文献类型：期刊论文

作者Guo, Zheng1; Yao, Jie1; Zheng X(郑旭)2; Cao, Jialing1; Lv, Xinxin1; Gao, Zheng3; Guo, Shuyu1; Li HY(李航宇)2; Guan DS(关东石)2; Li L(李龙)2
刊名CELL REPORTS
出版日期2025-03-01
卷号44期号:3页码:115342
关键词cavity oscillation EPI/PrE segregation pattern formation early mammalian embryos blastocyst
ISSN号2211-1247
DOI10.1016/j.celrep.2025.115342
英文摘要During the second cell fate in mouse embryos, the inner cell mass (ICM) segregates into the spatially distinct epiblast (EPI) and primitive endoderm (PrE) layers. The mechanism driving this pattern formation, however, remains unresolved. Here, we report that, concomitant with the segregation process of EPI/PrE precursors starting from mid-blastocyst, the blastocyst cavity begins to oscillate cyclically with rapid contraction yet slow expansion, triggering a phase transition in the ICM to a fluid-like state. This asymmetric oscillation of the blastocyst cavity facilitates EPI/PrE segregation by enhancing cell-cell contact fluctuations within the ICM and initiating convergent cell flows, which induce movement of these two cell types in opposite directions, wherein PrE precursors move toward the ICM-lumen interface, whereas EPI precursors move toward the trophectoderm. Last, we found that both PDGFRa expression and YAP nuclear accumulation in PrE precursors increase in response to blastocyst cavity oscillation. This study reveals the foundational role of physical oscillation in driving embryonic pattern formation during early mammalian embryonic development.
分类号二类/Q1
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001434277300001
资助机构Thanks to Professor Philippe Soriano of the Icahn School of Medicine at Mount Sinai for donating the Pdgfra H2B-GFP/+ mouse to us. This work was supported by the National Natural Science Foundation of China (12222201, 82273500, 12332019, U20A20390, 118278037, 32171274, 12272388, and 12232019) , the National Key R&D Program of China (2017YFA0506500, 2016YFC1102203, and 2016YFC1101100) , Young Elite Scientist Sponsorship Program by CAST (YESS 2015QNRC001) , the CAS Strategic Priority Research Program (XDB0620102) , Fundamental Research Funds for the Central Universities (ZG140S1971) , and the Youth Innovation Promotion Association CAS.
其他责任者Du, Jing，Fan, Yubo
源URL[http://dspace.imech.ac.cn/handle/311007/101470]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Beihang University;
2.Chinese Academy of Sciences Inst Mech;
3.Guangzhou Medical University;
4.Institute of Zoology, CAS;
5.Beijing University of Chemical Technology;
6.Tsinghua University;
7.Chinese Academy of Sciences Northwest Inst Plateau Biol
推荐引用方式
GB/T 7714		 Guo, Zheng,Yao, Jie,Zheng X,et al. Cavity oscillation drives pattern formation in early mammalian embryos[J]. CELL REPORTS,2025,44(3):115342.
APA Guo, Zheng.,Yao, Jie.,郑旭.,Cao, Jialing.,Lv, Xinxin.,...&Fan, Yubo.(2025).Cavity oscillation drives pattern formation in early mammalian embryos.CELL REPORTS,44(3),115342.
MLA Guo, Zheng,et al."Cavity oscillation drives pattern formation in early mammalian embryos".CELL REPORTS 44.3(2025):115342.

入库方式： OAI收割

来源：力学研究所

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