Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling
文献类型：期刊论文
| 作者 | Li, Yijie1; Yang, Yanyan1; Wang XH(王小环)1; Li L(李龙)2,3; Zhou, Mouwang1 |
| 刊名 | COMMUNICATIONS BIOLOGY
 |
| 出版日期 | 2025-03-01 |
| 卷号 | 8期号:1页码:1-12 |
| 关键词 | Cell migration Cell polarity Cell signalling |
| ISSN号 | 2399-3642 |
| DOI | 10.1038/s42003-025-07946-8 |
| 英文摘要 | For precise bone formation, osteoblasts need to accurately migrate to specific sites guided by various biochemical and mechanical cues. During this migration, fluctuations in extracellular osmolarity may arise from shifts in the surrounding fluid environment. However, as a main regulator of cell morphology and function, whether the extracellular osmolarity change may affect osteoblast migration remains unclear. Here, we provide evidence showing that changes in extracellular osmolarity significantly impact osteoblast migration, with a hypotonic environment enhancing it while a hypertonic environment inhibiting it. Further, our findings reveal that a hypotonic treatment increases intracellular pressure, activating the Transient Receptor Potential Vanilloid 4 (TRPV4) channel. This activation of TRPV4 modulates stress fibers, focal adhesions (FAs), and cell polarity through the Rho/ROCK signaling pathway, ultimately impacting osteoblast migration. Our findings provide valuable insights into the significant influence of extracellular osmolarity on osteoblast migration, which has potential implications for enhancing our understanding of bone remodeling. |
| 分类号 | 一类 |
| WOS研究方向 | Biology ; Multidisciplinary Sciences ; Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001454825400002 |
| 资助机构 | This work has been supported by the National Natural Science Foundation of China, Grant numbers: 82272597, 82072538, 12232019, and 12272388. |
| 其他责任者 | 王小环，李龙，Zhou, Mouwang |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/101475]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 作者单位 | 1.Peking University; 2.Chinese Academy of Sciences State Key Lab Nonlinear Mech; 3.Institute of Mechanics, CAS |
| 推荐引用方式 GB/T 7714 | Li, Yijie,Yang, Yanyan,Wang XH,et al. Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling[J]. COMMUNICATIONS BIOLOGY,2025,8(1):1-12. |
| APA | Li, Yijie,Yang, Yanyan,王小环,李龙,&Zhou, Mouwang.(2025).Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling.COMMUNICATIONS BIOLOGY,8(1),1-12. |
| MLA | Li, Yijie,et al."Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling".COMMUNICATIONS BIOLOGY 8.1(2025):1-12. |
入库方式： OAI收割
来源：力学研究所
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