Effects of orientation of myocardial fibers on the contractility of left ventricle
文献类型：期刊论文
| 作者 | Li, Peijin1,2 ; Sun, Anqiang3; Guo, Caixia4; Peng, Zhilong5; Wang, Chao1,2
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| 刊名 | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 168页码:10 |
| 关键词 | Myocardial fibers Orientation angle Contractility Left ventricle Non-linear finite element method |
| ISSN号 | 1751-6161 |
| DOI | 10.1016/j.jmbbm.2025.107025 |
| 通讯作者 | Wang, Chao(wangchao@lnm.imech.ac.cn) |
| 英文摘要 | Myocardial fibers of the left ventricle (LV) play a pivotal role in electrical conduction, mechanical contraction, and numerous clinical malfunctions. While the general fiber orientation of the LV has been revealed through histological analysis and magnetic resonance diffusion tensor imaging, its impact on LV deformation remains largely unknown. In this paper, we adopt an idealized hollow semi-ellipsoid LV model, allowing for adjustable fiber orientations using a widely-accepted rule-based method. Simulations are conducted using a robustly coupled excitation-contraction nonlinear finite element algorithm. Our primary focus is on exploring the orientation angle of regularly-distributed fibers and the proportion of chaotic fibers, whose orientation angles are randomly assigned, on the end-systolic volume and ejection fraction of the LV. By employing this model, we successfully recreate the changes in LV volume over a cardiac cycle and capture the typical twisting motion observed in clinical practice. Furthermore, our findings reveal that when myocardial fibers are regularly distributed and the orientation angle increases, the ejection fraction of the LV decreases along with an increase in end-systolic volume, indicating a decline in LV contractility. Additionally, both the proportion and spatial distribution of chaotic fibers within the LV influence its contractility. Specifically, an LV with a higher proportion of chaotic fibers in the basal area exhibits weaker contractility. These results provide deeper insights into the quantitative influence of myocardial fibers on LV contractility and failure, offering valuable information for further research and clinical applications. |
| WOS关键词 | HEART-FAILURE ; HISTOLOGICAL VALIDATION ; MODEL ; CARDIOLOGY ; COMMITTEE ; TISSUE |
| 资助项目 | NSFC[11972348] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001486373000001 |
| 资助机构 | NSFC |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/101561]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Wang, Chao |
| 作者单位 | 1.Chinese Acad Sci, LNM, Inst Mech, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 3.Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing 100083, Peoples R China 4.Capital Med Univ, Beijing Tongren Hosp, Cardiovasc Ctr, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China 5.Beijing Inst Technol, Sch Aerosp Engn, Dept Mech, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Peijin,Sun, Anqiang,Guo, Caixia,et al. Effects of orientation of myocardial fibers on the contractility of left ventricle[J]. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS,2025,168:10. |
| APA | Li, Peijin,Sun, Anqiang,Guo, Caixia,Peng, Zhilong,&Wang, Chao.(2025).Effects of orientation of myocardial fibers on the contractility of left ventricle.JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS,168,10. |
| MLA | Li, Peijin,et al."Effects of orientation of myocardial fibers on the contractility of left ventricle".JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 168(2025):10. |
入库方式： OAI收割
来源：力学研究所
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