Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight
文献类型：期刊论文
| 作者 | Du Y(杜宇)1,2,3 ; Han, Bing4; Biere, Katharina4; Abdelmalek, Nathalie4; Shu XY(舒芯钰)1,2,3; Song CY(宋超洋)1,2,3; Chen GY(陈光尧)1,2,3; Li, Ning1,2,3; Tuschen, Marina4; Wu, Huan1,2,3
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| 刊名 | NPJ MICROGRAVITY
 |
| 出版日期 | 2025-02-01 |
| 卷号 | 11期号:1页码:1-8 |
| 关键词 | Diseases Inflammation |
| ISSN号 | 2373-8065 |
| DOI | 10.1038/s41526-024-00456-7 |
| 英文摘要 | Returning to the moon and traveling to Mars represent the main targets of human space exploration missions within the upcoming decades. Comparable to microgravity, partial gravity in these destinations is assumed to dysregulate immune functions, thereby threatening astronauts health. To investigate the impact of partial gravity on immune cell attachment to vessel endothelia, THP-1 cells and HUVEC cell layers were monitored in a flow chamber system during parabolic flight in lunar (0.16 g) or Martian (0.38 g) gravity. Focus was set on floating speed, cell adhesion, surface molecule expression and cytoskeletal reorganization under basal and TNF-induced inflammatory environment. Floating speed of THP-1 cells was increased in partial gravity, which was accompanied by a successively lower adhesion to the endothelial HUVEC cells. Expression levels of the adhesion markers Mac-1 on THP-1 cells as well as ICAM-1 on HUVECs were found elevated in lunar and Martian gravity, which was aggravated by TNF. Analysis of cytoskeletal organization in HUVECs revealed reduced intracellular F-actin microfilament networks and a stronger cell directionality with stress fiber alignment at cell borders in partial gravity, which was intensified by TNF. In summary, altered immune cell - endothelium interactions as quantified in partial gravity conditions show similarities to cellular behavior in microgravity. However, the different magnitudes of effects in dependence of gravitational level still need to be assessed in further investigations. |
| 分类号 | 二类/Q1 |
| WOS研究方向 | Multidisciplinary Sciences ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001411939100001 |
| 资助机构 | Open Access funding enabled and organized by Projekt DEAL. This work was funded by the German National Space Program supported by the German Aerospace Center (DLR) on behalf of the Federal Ministry of Economics and Technology/Climate Action BMWi/K ; DLR grant 50WB2222. The authors are grateful for support from National Natural Science Foundation of China grant T2394514, 12372320, and China Manned Space Flight Technology Project Chinese Space Station Experiment Project YYWT0901EXP0701. The authors thank the entire Novespace staff for their support and the European Space Agency (ESA) for organization and implementation of the 81st ESA parabolic flight campaign. |
| 其他责任者 | Chouker, Alexander，龙勉 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/101473]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 作者单位 | 1.Chinese Academy of Sciences Inst Mech; 2.Institute of Mechanics, CAS; 3.University of Chinese Academy of Sciences, CAS; 4.University of Munich |
| 推荐引用方式 GB/T 7714 | Du Y,Han, Bing,Biere, Katharina,et al. Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight[J]. NPJ MICROGRAVITY,2025,11(1):1-8. |
| APA | 杜宇.,Han, Bing.,Biere, Katharina.,Abdelmalek, Nathalie.,舒芯钰.,...&Moser, Dominique.(2025).Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight.NPJ MICROGRAVITY,11(1),1-8. |
| MLA | 杜宇,et al."Lunar and Martian gravity alter immune cell interactions with endothelia in parabolic flight".NPJ MICROGRAVITY 11.1(2025):1-8. |
入库方式： OAI收割
来源：力学研究所
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