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Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242

文献类型：期刊论文

作者Dong, Guan-Hai1,2,3,4; Li, Xiao-Ming2,3,4; Wang, Ying1,3,4; Wang, Bin-Gui1,2,3,4; Meng, Ling-Hong1,2,3,4
刊名CHEMISTRY & BIODIVERSITY
出版日期2025-04-28
页码7
关键词antibacterial activiIntroduction deep-sea anemone endozoic fungus Talaromyces scorteus
ISSN号1612-1872
DOI10.1002/cbdv.202500726
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@qdio.ac.cn)
英文摘要Talarodride I (1), the first representative of penta-nor-nonadride derivative having a caged bicyclo[4.3.1]deca-2,6-diene core skeleton with an aldehyde group at C-15, together with a new congener talarodride J (2) and five known secondary metabolites (3-7), were isolated and identified from the Magellan seamount-sourced sea-anemone endozoic fungus Talaromyces scorteus AS-242. Their structures were assigned by nuclear magnetic resonance and mass spectroscopic data analysis and time-dependent density functional theory electronic circular dichroism calculations. In the antibacterial assays compounds 1-5 displayed activities against a broad spectrum of human- and aquatic pathogens, with compounds 1 and 2 showing potent inhibitory effects against Escherichia coli and Aeromonas hydrophilia (minimum inhibitory concentration values 1-4 mu g/mL).
WOS关键词FUNGUS ; CLEISTANTHANE ; DITERPENOIDS ; INHIBITORS ; CASSANE
资助项目National Natural Science Foundation of China[42176115] ; National Natural Science Foundation of China[41976090]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001477379400001
出版者WILEY-V C H VERLAG GMBH
源URL[http://ir.qdio.ac.cn/handle/337002/201704]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Meng, Ling-Hong
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
4.Chinese Acad Sci, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Guan-Hai,Li, Xiao-Ming,Wang, Ying,et al. Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242[J]. CHEMISTRY & BIODIVERSITY,2025:7.
APA Dong, Guan-Hai,Li, Xiao-Ming,Wang, Ying,Wang, Bin-Gui,&Meng, Ling-Hong.(2025).Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242.CHEMISTRY & BIODIVERSITY,7.
MLA Dong, Guan-Hai,et al."Talarodride I, an Unusual Penta-Nor-Nonadride and Other Derivatives Characterized From the Deep-Sea Seamount-sourced Endozoic Talaromyces scorteus AS-242".CHEMISTRY & BIODIVERSITY (2025):7.

入库方式： OAI收割

来源：海洋研究所

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