Cnidaria XIAP activates caspase-mediated cell death
文献类型：期刊论文
| 作者 | Chen, Yuan1,2,3,4 ; Wu, Meng1,2,3,4; Yuan, Zihao1,2,3,4; Wang, Qingyue1,2,3,4; Xu, Hang2,3,4; Sun, Li1,2,3,4
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2025-05-01 |
| 卷号 | 310页码:10 |
| 关键词 | XIAP Cnidaria Jellyfish Apoptosis Caspase |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.143427 |
| 通讯作者 | Xu, Hang(xuhang@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | In vertebrates, X-linked inhibitor of apoptosis (XIAP) is a potent inhibitor of apoptosis. XIAP inhibits apoptosis by interacting with proapoptotic caspases via its baculovirus IAP repeat (BIR) domains and mediating caspase ubiquitination via its really interesting new gene (RING) domain and ubiquitin-associated (UBA) domain. In invertebrates, and mainly in arthropods, XIAP is also known as an apoptosis inhibitor. However, no studies on basal metazoan XIAP have been documented to date. In the present work, we examined the biological activity of XIAP from the jellyfish Aurelia coerulea (AcXIAP) and other non-bilaterians. AcXIAP has three BIRs and one RING domain but lacks a UBA domain. AcXIAP enhanced the apoptosis-inducing activity of all four A. coerulea caspases identified in this study, including both initiator and effector clades. AcXIAP activated caspase via one of the BIRs, which bound and stabilized the caspase, and the RING domain, which mediated ubiquitination of the caspase p20 subunit in a lysine-independent manner. Similar caspase-activating properties were also observed in the XIAP of hydra, coral, and sponge. In hydra, XIAP knockdown markedly decreased cell death induced by an apoptosis inducer. Together these results revealed the unconventional function and working mechanism of XIAP in Cnidaria, and shed new light on the functional and structural evolution of XIAP. |
| WOS关键词 | APOPTOSIS PROTEIN IAP ; FUNCTIONAL-ANALYSIS ; INHIBITOR ; CLONING ; FAMILY ; PROTEASES |
| 资助项目 | Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203000] ; Innovation Research Group Project of the National Natural Science Foundation of China[42221005] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001483781500001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/201793]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Hang; Sun, Li |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Marine Sci, Qingdao, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 4.Chinese Acad Sci, CAS, Inst Oceanol, Ctr Ocean Mega Sci, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yuan,Wu, Meng,Yuan, Zihao,et al. Cnidaria XIAP activates caspase-mediated cell death[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,310:10. |
| APA | Chen, Yuan,Wu, Meng,Yuan, Zihao,Wang, Qingyue,Xu, Hang,&Sun, Li.(2025).Cnidaria XIAP activates caspase-mediated cell death.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,310,10. |
| MLA | Chen, Yuan,et al."Cnidaria XIAP activates caspase-mediated cell death".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 310(2025):10. |
入库方式： OAI收割
来源：海洋研究所
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