Non-coding RNA regulatory networks underlying intestinal degradation in Apostichopus japonicus under starvation stress: Insights from transcriptome analysis
文献类型：期刊论文
| 作者 | Ge, Lifei2; Wei, Ying2 ; Ye, Zhiqing2; Jiang, Zhijing2; Liu, Yuting2; Wang, Yibo2; Xu, Xiuwen2; Wang, Jixiu2; Yang, Jingwen2; Sun, Lina1
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2025-05-01 |
| 卷号 | 307页码:11 |
| 关键词 | Apostichopus japonicus Starvation stress Non-coding RNAs |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.142069 |
| 通讯作者 | Wang, Tianming(wangtianming@zjou.edu.cn) |
| 英文摘要 | Starvation stress is one of the most common environmental challenges faced by aquatic animals, often leading to compensatory growth, a widespread phenomenon in the animal kingdom, especially among aquatic species. The sea cucumber (Apostichopus japonicus), a key marine economic species in China, has been shown to utilize long non-coding RNAs (lncRNAs) in responding to environmental changes, pathogen infections, and tissue regeneration. In this study, strand-specific high-throughput sequencing was employed to analyze transcriptomic data from degenerated intestines of A. japonicus under starvation conditions. High-quality lncRNAs were identified and classified, and key differentially expressed mRNAs and lncRNAs associated with intestinal degradation were screened. A gene interaction network model based on the competing endogenous RNA (ceRNA) theory was then constructed. The analysis revealed that the "AjSOX9/Aja-miR-2012-5p/MSTRG.2956.1 and MSTRG.5699.1" axes, as well as the "AjWNT9B/Aja-miR-200-3p/MSTRG.19757.1 and MSTRG.21788.1" axes, play significant roles in degraded intestines and may promote intestinal regeneration during compensatory growth. Additionally, the "AjFABP2/Aja-miR-9-5p/MSTRG.9667.1" axis appears to regulate energy metabolism under starvation stress. These findings provide valuable insights into the non-coding gene regulatory networks in invertebrates under starvation stress and offer a scientific foundation for developing stress-resistant sea cucumber strains, contributing to the sustainable development of the sea cucumber aquaculture industry. |
| WOS关键词 | BURMESE PYTHON ; ANDEAN TOAD ; FLEXIBILITY ; EXPRESSION ; GROWTH ; GENES ; FISH |
| 资助项目 | National Natural Science Foundation of China[32373111] ; National Natural Science Foundation of China[32072952] ; Zhejiang Natural Science Foundation Outstanding Youth Grant[LR24C190001] ; The Pioneer and Leading Goose R&D Program of Zhejiang[2022C02040] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001468202900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/201650]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Wang, Tianming |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Shandong, Peoples R China 2.Zhejiang Ocean Univ, Marine Sci & Technol Coll, Natl Engn Lab Marine Germplasm Resources Explorat, Zhoushan 316022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Lifei,Wei, Ying,Ye, Zhiqing,et al. Non-coding RNA regulatory networks underlying intestinal degradation in Apostichopus japonicus under starvation stress: Insights from transcriptome analysis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,307:11. |
| APA | Ge, Lifei.,Wei, Ying.,Ye, Zhiqing.,Jiang, Zhijing.,Liu, Yuting.,...&Wang, Tianming.(2025).Non-coding RNA regulatory networks underlying intestinal degradation in Apostichopus japonicus under starvation stress: Insights from transcriptome analysis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,307,11. |
| MLA | Ge, Lifei,et al."Non-coding RNA regulatory networks underlying intestinal degradation in Apostichopus japonicus under starvation stress: Insights from transcriptome analysis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 307(2025):11. |
入库方式： OAI收割
来源：海洋研究所
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