Identification of candidate genes and SNPs associated with growth traits by genome-wide association study (GWAS) in sea cucumber (Apostichopus japonicus)
文献类型：期刊论文
| 作者 | Cui, Wei2,3,4,5 ; Su, Fang2,3,4,5; Liu, Shilin2,3,4,5; Zhang, Libin4,5; Yang, Hongsheng2,3,4,5; Rasoamananto, Irene1; Lavitra, Thierry1; Sun, Lina2,3,4,5
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| 刊名 | AQUACULTURE
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| 出版日期 | 2025-07-15 |
| 卷号 | 605页码:10 |
| 关键词 | Sea cucumber ( Apostichopus japonicus ) Growth traits GWAS Genomic selection |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2025.742512 |
| 通讯作者 | Sun, Lina(sunlina@qdio.ac.cn) |
| 英文摘要 | Growth traits are considered the most important production traits for aquatic animals. The genetic enhancement of growth traits has the potential to boost productivity, shorten breeding periods and reduce costs. We constructed four full-sib families of the same age to monitor the growth parameters of A. japonicus and observed a growth variation coefficient exceeding 50 %. To investigate the causes of significant growth variation between individuals, we performed genome-wide association analyses on 271 randomly selected A. japonicus. We identified 3 single nucleotide polymorphisms (SNPs) that showed a significant (- log10(P-value) = 7.65) association and 368 suggestively (- log10(P-value) = 5) association SNPs with growth using a linear mixed model (LMM). A total of 447 candidate genes linked to these SNPs were identified, some of which show a direct relationship with neuroimmunity, transcriptional regulation, signal transduction, substance metabolism, cell differentiation and development processes. These genes differ from growth axis hormone genes in fish, suggesting that the growth trait regulation mechanism of A. japonicus may be species-specific. Furthermore, we validated the differential expression of six genes between high-growth (H) group and low-growth (L) group, which may play crucial roles in the growth of A. japonicus. The results provide not only molecular markers for genetic improvement but also new insights into the regulatory mechanisms of the economically traits in A. japonicus. |
| WOS关键词 | METABOLISM ; EXPRESSION |
| 资助项目 | Key Technology Research and Development Program of Shandong[2021LZGC029] ; National Natural Science Foundation of China[42076093] ; National Natural Science Foundation of China[42276143] ; Shandong Provincial Natural Science Foundation[ZR2024YQ050] ; Taishan Scholars[tsqn202306279] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001469987100001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/201665]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Univ Toliara, Inst Halieut & Sci Marines IH SM, Toliara, Madagascar 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao 266071, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Wei,Su, Fang,Liu, Shilin,et al. Identification of candidate genes and SNPs associated with growth traits by genome-wide association study (GWAS) in sea cucumber (Apostichopus japonicus)[J]. AQUACULTURE,2025,605:10. |
| APA | Cui, Wei.,Su, Fang.,Liu, Shilin.,Zhang, Libin.,Yang, Hongsheng.,...&Sun, Lina.(2025).Identification of candidate genes and SNPs associated with growth traits by genome-wide association study (GWAS) in sea cucumber (Apostichopus japonicus).AQUACULTURE,605,10. |
| MLA | Cui, Wei,et al."Identification of candidate genes and SNPs associated with growth traits by genome-wide association study (GWAS) in sea cucumber (Apostichopus japonicus)".AQUACULTURE 605(2025):10. |
入库方式： OAI收割
来源：海洋研究所
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