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Hypertension and diabetes on cognitive impairment: a case-control study in China

文献类型：期刊论文

作者Wu, Jing1,2; Yin, Xiangjun1; Ji, Weiqiang3; Liu, Yang1,3; Tang, Jing4; Zhang, Han1; Qi, Shige1; Li, Jie5; Lin, Li4; Yang, Xueqing1
刊名ALZHEIMERS RESEARCH & THERAPY
出版日期2025-05-30
卷号17期号:1页码:120
关键词Cognitive impairment Hypertension Diabetes Elderly Case-control study
DOI10.1186/s13195-025-01761-3
产权排序6
文献子类Article
英文摘要BackgroundCognitive impairment, hypertension and diabetes are prevalent chronic conditions in populations of older ages. Previous studies have shown that hypertension and diabetes are risk factors for the development of cognitive impairment. However, the impact of hypertension combined with diabetes (HD) and their cumulative effects on cognitive impairment remain unclear. We aimed to investigate whether HD influences development of cognitive impairment and whether the effect is cumulative.MethodsA case-control study was conducted. From 40,103 subjects aged 60 years or older, enrolled from 28 representative communities of 9 provinces of China between January 2015 and December 2021 into the Prevention and Intervention on Neurodegenerative Disease for Elderly in China program using multi-stage stratified random sampling, individuals not meeting our propensity score matching criteria were excluded, and 13,252 individuals were finally selected for the study. Exposure factors included hypertension, diabetes and their comorbidity. Odds ratios (ORs) of exposure factors on cognitive impairment were measured using multiple logistic regression.ResultsWe found significant impacts of hypertension, diabetes and their comorbidity on cognitive impairment occurrence. The OR values for dementia were 1.18 for individuals with hypertension only, 1.26 for those with diabetes only, and 1.53 for those with HD. Compared to participants without hypertension and diabetes, the OR values for mild cognitive impairment (MCI) were 1.11 for individuals with hypertension only, 1.32 for those with diabetes only, and 1.27 for those with HD. For subjects with HD longer than 5 years, the comorbidity significantly impacted on MCI and dementia, and the degree of impact increased with the duration of comorbidity. For hypertension, the influence of hypertension on dementia were most influential in middle-aged (45-64 years old) people. By contrast, the influence of diabetes on people younger than 45-year-old was most significant, with the middle-age group being the second most impacted subjects.ConclusionsThe elderly with HD have a heightened risk of developing cognitive impairment, particularly dementia, compared to those with either hypertension or diabetes alone. The study revealed a significant cumulative impact of HD on cognitive impairment.
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WOS关键词DEMENTIA
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001499619400001
出版者BMC
源URL[http://ir.igsnrr.ac.cn/handle/311030/214640]  
专题资源与环境信息系统国家重点实验室_外文论文
通讯作者Wu, Jing; Xu, Chengdong; Du, Qingfeng
作者单位1.Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China;
2.Guangdong Basic Res Ctr Excellence Integrated Trad, Guangzhou 510515, Peoples R China;
3.Southern Med Univ, Hosp Integrated Tradit Chinese & Western Med, Guangzhou 510315, Peoples R China;
4.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China;
5.Guangzhou Univ, Sch Geog & Remote Sensing, Guangzhou 510006, Peoples R China;
6.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China;
7.Guangdong Prov Key Lab Chinese Med Pharmaceut, Guangzhou 510515, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Jing,Yin, Xiangjun,Ji, Weiqiang,et al. Hypertension and diabetes on cognitive impairment: a case-control study in China[J]. ALZHEIMERS RESEARCH & THERAPY,2025,17(1):120.
APA Wu, Jing.,Yin, Xiangjun.,Ji, Weiqiang.,Liu, Yang.,Tang, Jing.,...&Du, Qingfeng.(2025).Hypertension and diabetes on cognitive impairment: a case-control study in China.ALZHEIMERS RESEARCH & THERAPY,17(1),120.
MLA Wu, Jing,et al."Hypertension and diabetes on cognitive impairment: a case-control study in China".ALZHEIMERS RESEARCH & THERAPY 17.1(2025):120.

入库方式： OAI收割

来源：地理科学与资源研究所

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