Eco-friendly synthesis of gold nanoparticles using Equisetum diffusum D. Don. with broad-spectrum antibacterial, anticancer, antidiabetic, and antioxidant potentials
文献类型：期刊论文
| 作者 | Assad, Nasir2; Laila, Marzia Batool2; Hassan, Muhammad Naeem Ul2; Rehman, Muhammad Fayyaz ur2; Ali, Liaqat2; Mustaqeem, Muhammad2; Ullah, Barkat3; Khan, Muhammad Nauman3,4; Iqbal, Majid5,6; Ercisli, Sezai1,7 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2025-06-02 |
| 卷号 | 15期号:1页码:19246 |
| 关键词 | Green synthesis Gold nanoparticles Equisetum diffusum Anticancer activity Antidiabetic activity Antioxidant activity |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-025-02450-9 |
| 产权排序 | 4 |
| 文献子类 | Article |
| 英文摘要 | The present study reports, the eco-friendly synthesis of gold nanoparticles (AuNPs) using Equisetum diffusum D. Don. extract, a medicinal plant known for its therapeutic properties. Phytochemicals present in the extract served as reducing and stabilizing agents for synthesizing stable AuNPs with an average size range of 68.8 nm. The biosynthesized AuNPs were characterized using UV-vis spectroscopy, FTIR, XRD, SEM, EDX, and dynamic light scattering (DLS) methods, confirming their stability, morphology, and crystalline nature. The green synthesized ED@AuNPs exhibited promising biological activities, including broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, with inhibition zones from 24 to 37 mm. The anticancer activity was assessed through an MTT assay against hepatic carcinoma (HePG2) cells, revealing dose-dependent cytotoxicity with maximum inhibition at 200 mu g/mL (47.62%). Antidiabetic activity was demonstrated by starch hydrolysis and enzyme kinetics, with significant alpha-amylase inhibitory activity up to 70.85%, comparable to the standard drug Acarbose. Moreover, antioxidant activity was conformed through FRAP and DPPH assays, indicating strong free radical scavenging activity and reducing ability. The study demonstrates the potential of biosynthesized ED@AuNPs as multifunctional agents with applications in biomedicine, particularly in antibacterial, anticancer, antidiabetic, and antioxidant therapies, offering an eco-friendly and sustainable approach for nanoparticle synthesis. |
| URL标识 | 查看原文 |
| WOS关键词 | SILVER NANOPARTICLES ; GREEN SYNTHESIS ; RESISTANT BACTERIAL ; ANTIMICROBIAL AGENT ; BIOSYNTHESIS ; EXTRACT ; AUNPS |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001501594400022 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/214542]  |
| 专题 | 生态系统网络观测与模拟院重点实验室_外文论文 |
| 通讯作者 | Malik, Tabarak |
| 作者单位 | 1.HGF Agro, Ata Teknokent, Erzurum, Turkiye; 2.Univ Sargodha, Inst Chem, Sargodha 40100, Pakistan; 3.Islamia Coll Peshawar, Dept Bot, Peshawar 25120, Pakistan; 4.Univ Peshawar, Univ Publ Sch, Biol Lab, Peshawar 25120, Pakistan; 5.Chinese Acad Sci, Key Lab Ecosyst Network Observat & Modeling, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China; 6.Univ Chinese Acad Sci UCAS, Beijing 100049, Peoples R China; 7.Ataturk Univ, Agr Fac, Dept Hort, Erzurum, Turkiye; 8.King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia; 9.Guru Jambheshwar Univ Moradabad, Hindu Coll Moradabad, Dept Bot, Moradabad 244001, Uttar Pradesh, India; 10.Jimma Univ, Inst Hlth, Dept Biomed Sci, Jimma 378, Ethiopia; |
| 推荐引用方式 GB/T 7714 | Assad, Nasir,Laila, Marzia Batool,Hassan, Muhammad Naeem Ul,et al. Eco-friendly synthesis of gold nanoparticles using Equisetum diffusum D. Don. with broad-spectrum antibacterial, anticancer, antidiabetic, and antioxidant potentials[J]. SCIENTIFIC REPORTS,2025,15(1):19246. |
| APA | Assad, Nasir.,Laila, Marzia Batool.,Hassan, Muhammad Naeem Ul.,Rehman, Muhammad Fayyaz ur.,Ali, Liaqat.,...&Malik, Tabarak.(2025).Eco-friendly synthesis of gold nanoparticles using Equisetum diffusum D. Don. with broad-spectrum antibacterial, anticancer, antidiabetic, and antioxidant potentials.SCIENTIFIC REPORTS,15(1),19246. |
| MLA | Assad, Nasir,et al."Eco-friendly synthesis of gold nanoparticles using Equisetum diffusum D. Don. with broad-spectrum antibacterial, anticancer, antidiabetic, and antioxidant potentials".SCIENTIFIC REPORTS 15.1(2025):19246. |
入库方式： OAI收割
来源：地理科学与资源研究所
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