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Polycomponent metal-organic frameworks of substituent polydispersion hydroxypropyl-β-cyclodextrin as inhalable drug carrier

文献类型：期刊论文

作者He, Xiaojian2,6,7; Xu, Huipeng6; Zhao, Xiangyu2,5,6; Li, Feng4,6; Peng, Ningning2,5,6; Wang, Jialong4,6; Hua, Wenqiang3; Wang, Feixiang3; Xu, Guanghong2; Yang, Rui1
刊名CARBOHYDRATE POLYMERS
出版日期2025-08-15
卷号362页码:12
关键词Metal-organic frameworks Polycomponent Hydroxypropyl-beta-cyclodextrin Polydispersion Inhalation delivery
ISSN号0144-8617
DOI10.1016/j.carbpol.2025.123696
通讯作者Zhang, Jiwen(jwzhang@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要Cyclodextrin metal-organic frameworks (CD-MOFs) have garnered considerable attention for their unique porous structure, outstanding properties and diverse pharmaceutical applications. To date, all reported CD-MOFs have been synthesized using natural cyclodextrins (CDs) with periodic structures as organic ligands, while the most widely applied CD derivatives like hydroxypropyl-beta-cyclodextrin (HCD) have not been used as organic ligands for MOFs formation. Herein, we showed that the substituent polydispersion HCD coordinated with sodium ions to form polycomponent metal-organic frameworks (HCD-pMOFs), in which up to 21 stochastically substituted hydroxypropyl groups on each HCD resulted in compositional disorder. Multiple coordination modes between HCD and sodium ions resulted in the formation of cavities with sizes of 2.65 nm and 3.40 nm. It was hypothesized that the supramolecular structural units of HCD-pMOFs were constructed based on the molar ratio of HCD and sodium ions. Additionally, HCD-pMOFs exhibited the ability to improve thermal stability via solidification of volatile components, as conclusively demonstrated through eugenol stabilization experiments. In inhalation drug delivery applications, HCD-pMOFs showed excellent in vitro deposition performance and inhalation safety. Consequently, the synthesis of HCD-pMOFs furnishes a strategy for the MOFs made of derivatized cyclodextrins, and presents a novel type of carriers for inhalation drug delivery.
资助项目National Natural Science Foundation of China[82273863]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001487129000001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/317890]  
专题中国科学院上海药物研究所
通讯作者Zhang, Jiwen; Wu, Li
作者单位1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
2.Jiangsu Yungou Pharmaceut Technol Co Ltd, Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
6.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
7.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
推荐引用方式
GB/T 7714		 He, Xiaojian,Xu, Huipeng,Zhao, Xiangyu,et al. Polycomponent metal-organic frameworks of substituent polydispersion hydroxypropyl-β-cyclodextrin as inhalable drug carrier[J]. CARBOHYDRATE POLYMERS,2025,362:12.
APA He, Xiaojian.,Xu, Huipeng.,Zhao, Xiangyu.,Li, Feng.,Peng, Ningning.,...&Wu, Li.(2025).Polycomponent metal-organic frameworks of substituent polydispersion hydroxypropyl-β-cyclodextrin as inhalable drug carrier.CARBOHYDRATE POLYMERS,362,12.
MLA He, Xiaojian,et al."Polycomponent metal-organic frameworks of substituent polydispersion hydroxypropyl-β-cyclodextrin as inhalable drug carrier".CARBOHYDRATE POLYMERS 362(2025):12.

入库方式： OAI收割

来源：上海药物研究所

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