Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO-)
文献类型：期刊论文
| 作者 | Han, Hai-Hao3,4,5,6,7,8,9; Ge, Pan-Xin2,5; Li, Wen-Jia3,4,5; Hu, Xi-Le6,7,8,9; He, Xiao-Peng1,6,7,8,9 |
| 刊名 | SENSORS
 |
| 出版日期 | 2025-05-10 |
| 卷号 | 25期号:10页码:41 |
| 关键词 | peroxynitrite (ONOO-) fluorescent probes bioimaging in vivo disease diagnosis and treatment |
| DOI | 10.3390/s25103018 |
| 通讯作者 | He, Xiao-Peng(xphe@ecust.edu.cn) |
| 英文摘要 | Peroxynitrite (ONOO-) is a reactive nitrogen species (RNS) that plays pivotal roles in various physiological and pathological processes. The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO- dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO- and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO-. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO- probes from translating into clinical practice. |
| WOS关键词 | IMAGING ENDOGENOUS PEROXYNITRITE ; DRUG-INDUCED HEPATOTOXICITY ; INFARCT SIZE ; LIVING CELLS ; NITRIC-OXIDE ; LIVE CELLS ; MITOCHONDRIA ; EMISSION ; LYSOSOME ; SIGNALS |
| 资助项目 | National Natural Science Foundation of China ; Science and Technology Commission of Shanghai Municipality[24DX1400200] ; International Cooperation Program of Shanghai Science and Technology[23490711600] ; Shanghai Oriental Talents youth Program[QNKJ2024010] ; Shanghai Xuhui District Hospital Local Cooperation Project[23XHYD-20] ; Open Funding Project of the State Key Laboratory of Fine Chemicals, Dalian University of Technology[KF 2402] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University ; Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University)[2023-MEKLLC-MS/ZD-00*] ; Shandong Laboratory Program[SYS202205] ; Taishan Scholars Program[tsqn202312305] ; Young Elite Scientists Sponsorship Program by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ059] ; Key R&D Program of Shandong[2024CXPT028] ; [92253306] ; [22477030] ; [22107029] ; [22377135] |
| WOS研究方向 | Chemistry ; Engineering ; Instruments & Instrumentation |
| 语种 | 英语 |
| WOS记录号 | WOS:001497578700001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317974]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | He, Xiao-Peng |
| 作者单位 | 1.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China 2.Anhui Univ Chinese Med, Sch Pharm, Hefei 230031, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Natl Ctr Drug Screening,Stake Key Lab Chem Biol, Shanghai 201203, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 6.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 7.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 8.East China Univ Sci & Technol, Sch Chem & Mol Engn, Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 9.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat & Joint Int Res, 130 Meilong Rd, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Hai-Hao,Ge, Pan-Xin,Li, Wen-Jia,et al. Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO-)[J]. SENSORS,2025,25(10):41. |
| APA | Han, Hai-Hao,Ge, Pan-Xin,Li, Wen-Jia,Hu, Xi-Le,&He, Xiao-Peng.(2025).Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO-).SENSORS,25(10),41. |
| MLA | Han, Hai-Hao,et al."Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO-)".SENSORS 25.10(2025):41. |
入库方式： OAI收割
来源：上海药物研究所
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