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Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference

文献类型：期刊论文

作者Cheng, Ying-jie4; Zan, Gui-ying3; Deng, Ying-zhi4; Deng, Di4; Wu, Man-qing4; Chai, Jing-rui3; Wang, Yu-jun3; Liu, Jing-gen2,3; Zhao, Min1,4
刊名NATURE COMMUNICATIONS
出版日期2025-05-23
卷号16期号:1页码:13
DOI10.1038/s41467-025-59859-z
通讯作者Liu, Jing-gen(jgliu@simm.ac.cn) ; Zhao, Min(drminzhao@smhc.org.cn)
英文摘要Methamphetamine (METH) is a highly addictive psychostimulant, yet its addiction mechanisms remain unclear. Oxytocin (OXT), a neuropeptide, shows promise in reducing METH addiction, but how OXT exerts its effects is poorly understood. Using conditioned place preference (CPP), we first found that intranasal OXT other than Arginine Vasopressin (AVP) administration suppressed METH-CPP in mice, which could be reversed by OXT receptors (OXTRs) blockade in the nucleus accumbens (NAc) core. Activating OXTRs in the NAc core similarly reduced METH-CPP. Then, we found repeated METH exposure inhibited oxytocinergic neurons within the paraventricular nucleus (PVN) and lowered PVN OXT protein level. Chemogenetic activation of PVN oxytocinergic neurons (PVNOXT) blocked METH-CPP. Furthermore, METH inhibited PVNOXT-NAc core circuit other than PVNOXT-NAc shell circuit. Activation of PVNOXT-NAc core circuit significantly inhibited METH-CPP. This study reveals METH may impair the endogenous OXT system, especially the PVNOXT-NAc core circuit, highlighting OXT's therapeutic potential for METH use disorder (MUD).
WOS关键词PREFRONTAL CORTEX ; INDUCED REINSTATEMENT ; SUBTHALAMIC NUCLEUS ; SEEKING ; VASOPRESSIN ; NEURONS ; FEMALE ; BRAIN ; INVOLVEMENT ; DEPENDENCE
资助项目This work was supported by grant from the National Nature Science Foundation (82130041 to M.Z.).[82130041] ; National Nature Science Foundation
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001494395400009
出版者NATURE PORTFOLIO
源URL[http://119.78.100.183/handle/2S10ELR8/317980]  
专题中国科学院上海药物研究所
通讯作者Liu, Jing-gen; Zhao, Min
作者单位1.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
2.Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurobiol Zhejiang Prov, Hangzhou, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Ying-jie,Zan, Gui-ying,Deng, Ying-zhi,et al. Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference[J]. NATURE COMMUNICATIONS,2025,16(1):13.
APA Cheng, Ying-jie.,Zan, Gui-ying.,Deng, Ying-zhi.,Deng, Di.,Wu, Man-qing.,...&Zhao, Min.(2025).Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference.NATURE COMMUNICATIONS,16(1),13.
MLA Cheng, Ying-jie,et al."Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference".NATURE COMMUNICATIONS 16.1(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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