4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis
文献类型：期刊论文
| 作者 | He, Zhong4,5,6; Long, Hui6; Ma, Hongyue6; Ran, Wanrong5; Song, Yinhong3,5; Shang, Wenjuan2; Wang, Junhui1; Qin, Ye4,5,6; Deng, Zhangshuang6 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 183页码:10 |
| 关键词 | 4, 9-dihydroxy-alpha-lapachone Ferroptosis TNBC GPX4 |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106567 |
| 英文摘要 | Triple-negative breast cancer (TNBC) is the most aggressive and malignant breast cancer. Ferroptosis is an oxidative, iron-dependent form of regulated cell death. Ferroptosis-targeted therapies is a promising approach to improving treatment outcomes of TNBC. Combining death pathway inhibitors with relevant indices for ferroptosis and LipROS, this study uncovered that a natural product of 4, 9-dihydroxy-alpha-lapachone (DLN) from Catalpa bungei "jinsi" exhibited in vitro and in vivo inhibitory activity against TNBC via ferroptosis. The molecular mechanism is an activation of the FTH1 led to iron overload, and then inhibition of cysteine-glutamate antiporter (system Xc-) and GPX4, which further sensitized TNBC cells to ferroptosis. This study clarified the pathway of DLN-induced cell death in TNBC treatment and exhibited its potential as therapeutic agent for TNBC. |
| WOS关键词 | STATISTICS |
| 资助项目 | National Key Research and Develop-ment Program of China[2021YFD2200301] ; National Natural Science Foundation of China[81671397] ; Open-ing Foundation of Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province[2020KZL01] ; Yichang Applied Basic Research Project[A23-2-053] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001482503100002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317896]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Junhui; Qin, Ye; Deng, Zhangshuang |
| 作者单位 | 1.Chinese Acad Forestry, Res Inst Forestry, Key Lab Tree Breeding & Cultivat, State Forestry Adm,State Key Lab Tree Genet & Bree, Beijing 100091, Peoples R China 2.Hubei Three Gorges Polytech, Med Coll, Yichang 443000, Peoples R China 3.China Three Gorges Univ, Inst Infect & Inflammat, Yichang 443002, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.China Three Gorges Univ, Coll Basic Med Sci, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Peoples R China 6.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Zhong,Long, Hui,Ma, Hongyue,et al. 4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis[J]. FITOTERAPIA,2025,183:10. |
| APA | He, Zhong.,Long, Hui.,Ma, Hongyue.,Ran, Wanrong.,Song, Yinhong.,...&Deng, Zhangshuang.(2025).4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis.FITOTERAPIA,183,10. |
| MLA | He, Zhong,et al."4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis".FITOTERAPIA 183(2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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